Impaired cognitive function in women with congenital adrenal hyperplasia

Context: Congenital adrenal hyperplasia (CAH) is a disorder with a wide spectrum of severity. Objective: The objective of this study was to investigate cognitive function in CAH women. Design: This was a case-control study. Setting: This study was conducted at a tertiary center for pediatric endocrinology at the University Hospital of Copenhagen. Participants: Thirty-five Danish CAH women ( age 17 - 51 yr) were included, and participation rate was 84%. Control women were recruited through the Danish Civil Registration System and matched on age and education. Main Outcome Measures: An abbreviated form of the Wechsler Adult Intelligence Scale was used, i.e. full-scale intelligence quotient IQ; five of 11 subtests), which included three of six verbal IQ subtests and two of five performance IQ subtests. Results: A significantly lower IQ was found in CAH patients compared with controls with respect to mean full-scale IQ ( 84.5 vs. 99.1; P < 0.001), mean verbal IQ (86.6 vs. 97.3; P < 0.001), and mean performance IQ (85.7 vs. 101.3; P < 0.001). The salt-wasting CAH group had lower IQ scores than the simple-virilizing CAH group, which reached significance for mean total IQ (81.2 vs. 92.8, P = 0.04) and mean verbal IQ (84.7 vs. 95.5, P = 0.05), and additionally, lower scores than the late-onset CAH group, which reached significance for performance IQ ( mean 81.5 vs. 96.2, P = 0.02). Conclusions: Impaired cognitive function was observed in patients with CAH, especially in salt-wasting CAH. These intriguing findings may reflect adverse effects of hyponatremic episodes, suboptimal postnatal hormone replacement therapy or prenatal adrenal androgen excess, and the potential psychosocial consequences of the disorder.