Preliminary investigations on the synthesis and antitumor activity of 3(2H)-furanones

被引：23
|
作者：
Rappai, J. P. [1 ]
Raman, V. [1 ]
Unnikrishnan, P. A. [1 ]
Prathapan, S. [1 ]
Thomas, S. K. [2 ]
Paulose, C. S. [2 ]
机构：
[1] Cochin Univ Sci & Technol, Dept Appl Chem, Kochi 682022, Kerala, India
[2] Cochin Univ Sci & Technol, Dept Biotechnol, Kochi 682022, Kerala, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期
关键词：
Furanone; Dibenzoylstyrene; Bromofuran; Antitumor agent; Furan oxidation; UNSATURATED 1,4-DIKETONES; INHIBITORS; DERIVATIVES; LACTONES;
D O I：
10.1016/j.bmcl.2008.12.030
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two triaryl-3(2H)-furanones were synthesized and their antitumor activity was evaluated. These compounds inhibited the proliferation of DLA cell line in vitro. In vivo studies also showed that these compounds were active against tumor cell proliferation. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：764 / 765
页数：2
相关论文
共 50 条
  • [1] Cycloisomerization of Bifunctionalized Allenes: Synthesis of 3(2H)-Furanones in Water
    Poonoth, Manojkumar
    Krause, Norbert
    JOURNAL OF ORGANIC CHEMISTRY, 2011, 76 (06) : 1934 - 1936
  • [2] Carbon dioxide-mediated synthesis of 3(2H)-furanones from diyne alcohols
    Yuan, Gaoqing
    He, Zaijun
    Zheng, Junhua
    Chen, Zhengwang
    Huang, Huawen
    Shi, Dabin
    Qi, Chaorong
    Jiang, Huanfeng
    TETRAHEDRON LETTERS, 2011, 52 (45) : 5956 - 5959
  • [3] A Serendipitous Synthesis of Bis-Heterocyclic Spiro 3(2H)-Furanones
    Picado, Alfredo
    Li, ShengJian
    Dieter, R. Karl
    JOURNAL OF ORGANIC CHEMISTRY, 2016, 81 (04) : 1391 - 1400
  • [4] Synthesis of 4-Halo-3(2H)-furanones Using Intramolecular Cyclization of Sulfonium Salts
    Inagaki, Sho
    Nakazato, Maiko
    Fukuda, Nozomi
    Tamura, Satoru
    Kawano, Tomikazu
    JOURNAL OF ORGANIC CHEMISTRY, 2017, 82 (11) : 5583 - 5589
  • [5] Synthesis and antitumor activity evaluation of 2-arylisoquinoline-1,3(2H,4H)-diones in vitro and in vivo
    Kang, Bo-Rui
    Wang, Juan
    Li, Huan
    Li, Yan
    Mei, Qi-Bing
    Zhang, San-Qi
    MEDICINAL CHEMISTRY RESEARCH, 2014, 23 (03) : 1340 - 1349
  • [6] 3(2H)-Furanones promising candidates for synthesis of new fluorescent organic probes
    Soliman, Mohamed H. A.
    Hussein, Belal H. M.
    Abdel-Moati, Nahla
    El-Tamany, El-Sayed H. M.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2018, 57 (04): : 567 - 575
  • [7] One-pot tandem synthesis of fluorescent 5-naphthy1-3(2H)-furanones
    Mal'kina, Anastasiya G.
    Volostnykh, Ol'ga G.
    Petrushenko, Konstantin B.
    Shemyakina, Olesya A.
    Nosyreva, Valentina V.
    Ushakov, Igor' A.
    Trofimov, Boris A.
    TETRAHEDRON, 2013, 69 (18) : 3714 - 3720
  • [8] Cationic Gold(I)-Catalyzed Intramolecular Cyclization of γ-Hydroxyalkynones into 3(2H)-Furanones
    Egi, Masahiro
    Azechi, Kenji
    Saneto, Moriaki
    Shimizu, Kaori
    Akai, Shuji
    JOURNAL OF ORGANIC CHEMISTRY, 2010, 75 (06) : 2123 - 2126
  • [9] Functionalized 3(2H)-furanones via photooxygenation of (β-keto)-2-substituted furans: Application to the biomimetic synthesis of merrekentrone C
    Gryparis, Charis
    Lykakis, Ioannis N.
    Efe, Christina
    Zaravinos, Ioannis-Panayotis
    Vidali, Theonymphi
    Kladou, Eugenia
    Stratakis, Manolis
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 9 (16) : 5655 - 5658
  • [10] Synthesis of 5-Aryl-3(2H)-furanones Using Intramolecular Cyclization of Sulfonium Salts
    Inagaki, Sho
    Saito, Kai
    Suto, Soichiro
    Aihara, Hiromi
    Sugawara, Aoi
    Tamura, Satoru
    Kawano, Tomikazu
    JOURNAL OF ORGANIC CHEMISTRY, 2018, 83 (22) : 13834 - 13846
12345