Interaction of metallothionein with tumor suppressor p53 protein

被引：91

作者：

Ostrakhovitch, EA

Olsson, PE

Jiang, S ^{[1
]}

Cherian, MG

机构：

[1] Univ Western Ontario, Dept Pathol, London, ON N6A 5C1, Canada

[2] Univ Orebro, Dept Nat Sci, Orebro Life Sci Ctr, S-70130 Orebro, Sweden

来源：

FEBS LETTERS | 2006年 / 580卷 / 05期

关键词：

p53; metallothionein; protein interaction;

D O I：

10.1016/j.febslet.2006.01.036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous reports have shown that metallothionein (MT) may modulate p53 activity through zinc exchange. However, little is known on a direct interaction between MT and p53 in cells. The results demonstrate an interaction between MT and p53 can occur in vitro. The complex between MT and p53 was observed in breast cancer epithelial cells with both wild and inactive type of p53. Furthermore, it was shown that wt-p53 was preferentially associated with Apo-MT. Our data suggest that co-expression of MT and p53 and their complex formation in tumor cells may be involved in regulation of apoptosis in these cells. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1235 / 1238

页数：4

共 21 条

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