PEO-b-PCL block copolymers:: Synthesis, detailed characterization, and selected micellar drug encapsulation behavior

被引：89
作者：
Meier, MAR
Aerts, SNH
Staal, BBP
Rasa, M
Schubert, US
机构：
[1] Eindhoven Univ Technol, Lab Macromol Chem & Nanosci, NL-5600 MB Eindhoven, Netherlands
[2] DPI, NL-5600 MB Eindhoven, Netherlands
[3] Eindhoven Univ Technol, Polymer Technol Grp, NL-5600 MB Eindhoven, Netherlands
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2005年 / 26卷 / 24期
关键词：
block copolymers; combinatorial materials research; drug encapsulation; MALDI-TOF MS; micelles;
D O I：
10.1002/marc.200500591
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A series of poly(ethylene glycol)-block-poly(epsilon-caprolactone) diblock copolymers was synthesized and fully characterized. In particular, MALDI-TOF MS results revealed interesting new insights into their molecular architecture. Small and defined micelles could be prepared from these block copolymers. Utilizing a high-throughput screening approach, it was observed that these micelles are able to encapsulate/solubilize different guest molecules (e.g. drugs) depending on the solubility of the guest in water. Furthermore, it could be proven that a guest is located within a micelle and that these micelles can be utilized as transport vehicles for the encapsulated guest molecules.
引用
收藏
页码：1918 / 1924
页数：7
相关论文
共 30 条
[1]   Polycaprolactone-b-poly(ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone [J].
Allen, C ;
Han, JN ;
Yu, YS ;
Maysinger, D ;
Eisenberg, A .
JOURNAL OF CONTROLLED RELEASE, 2000, 63 (03) :275-286
[2]   Compatibilization of high-impact density polyethylene/high-density polystyrene blends by styrene/ethylene-butylene/styrene block copolymer [J].
Chirawithayaboon, A ;
Kiatkamjornwong, S .
JOURNAL OF APPLIED POLYMER SCIENCE, 2004, 91 (02) :742-755
[3]   POLYSTYRENE-POLY(ETHYLENE GLYCOL) (PS-PEG2000) PARTICLES AS MODEL SYSTEMS FOR SITE-SPECIFIC DRUG-DELIVERY .2. THE EFFECT OF PEG SURFACE-DENSITY ON THE IN-VITRO CELL-INTERACTION AND IN-VIVO BIODISTRIBUTION [J].
DUNN, SE ;
BRINDLEY, A ;
DAVIS, SS ;
DAVIES, MC ;
ILLUM, L .
PHARMACEUTICAL RESEARCH, 1994, 11 (07) :1016-1022
[4]   Enzymatic biodegradation of poly(ethylene oxide-b-ε-caprolactone) diblock copolymer and its potential biomedical applications [J].
Gan, ZH ;
Jim, TF ;
Li, M ;
Yuer, Z ;
Wang, SG ;
Wu, C .
MACROMOLECULES, 1999, 32 (03) :590-594
[5]   'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG):: influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption [J].
Gref, R ;
Lück, M ;
Quellec, P ;
Marchand, M ;
Dellacherie, E ;
Harnisch, S ;
Blunk, T ;
Müller, RH .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2000, 18 (3-4) :301-313
[6]  
Hecht S, 2001, ANGEW CHEM INT EDIT, V40, P74, DOI 10.1002/1521-3773(20010105)40:1<74::AID-ANIE74>3.0.CO
[7]  
2-C
[8]  
Kowalski A, 1998, MACROMOL RAPID COMM, V19, P567, DOI 10.1002/(SICI)1521-3927(19981101)19:11<567::AID-MARC567>3.0.CO
[9]  
2-T
[10]   Simple synthesis of poly(acetylene) latex particles in aqueous media [J].
Krause, JO ;
Zarka, MT ;
Anders, U ;
Weberskirch, R ;
Nuyken, O ;
Buchmeiser, MR .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (48) :5965-5969
123