Lactoferrin: Antimicrobial activity and therapeutic potential

被引：92
|
作者：
Embleton, Nicholas D. [1 ,2 ]
Berrington, Janet E. [1 ,2 ]
McGuire, William [3 ]
Stewart, Chris J. [4 ]
Cummings, Stephen P. [4 ]
机构：
[1] Newcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Neonatal Serv, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
[2] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[3] Univ York, Ctr Reviews & Disseminat, Natl Inst Hlth Res, York YO10 5DD, N Yorkshire, England
[4] Northumbria Univ, Sch Life Sci, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England
来源：
SEMINARS IN FETAL & NEONATAL MEDICINE | 2013年 / 18卷 / 03期
关键词：
Lactoferrin; Late-onset infection; Microbiome; Necrotising enterocolitis; RECOMBINANT HUMAN LACTOFERRIN; PREVENTING PRETERM DELIVERY; NECROTIZING ENTEROCOLITIS; BOVINE LACTOFERRIN; RANDOMIZED-TRIAL; MILK-PROTEINS; ESCHERICHIA-COLI; NEONATAL SEPSIS; GUT MICROBIOTA; INFANTS;
D O I：
10.1016/j.siny.2013.02.001
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Lactoferrin is a highly conserved protein from an evolutionary perspective, with a wide range of roles related to protection from infection and promotion of nutritional status. Infection, malnutrition and intestinal pathologies are key inter-related problems, represent important threats to survival and are associated with adverse long-term health outcomes after preterm birth. Lactoferrin is available as a commercial extract from bovine milk and offers potential as a therapeutic intervention for preterm infants modulating infections and intestinal pathologies. In this review we explore the structure, direct antimicrobial effects, modification of host immune function and gastrointestinal effects of lactoferrin. Current trial data are reviewed, and research priorities and challenges identified and discussed. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：143 / 149
页数：7
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