Glucose sensing by ChREBP/MondoA-Mlx transcription factors

被引：76

作者：

Havula, Essi ^{[1
]}

Hietakangas, Ville ^{[1
]}

机构：

[1] Univ Helsinki, Inst Biotechnol, Helsinki 00014, Finland

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2012年 / 23卷 / 06期

基金：

芬兰科学院; 欧洲研究理事会;

关键词：

Glucose sensing; Metabolism; Transcription; CARBOHYDRATE-RESPONSE ELEMENT; BINDING-PROTEIN CHREBP; THIOREDOXIN-INTERACTING-PROTEIN; WILLIAMS-BEUREN-SYNDROME; PYRUVATE-KINASE GENE; POLYUNSATURATED FATTY-ACIDS; X-RECEPTOR LXR; CENTER-DOT-MLX; L-PK GENE; HEPATIC STEATOSIS;

D O I：

10.1016/j.semcdb.2012.02.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The paralogous transcription factors ChREBP and MondoA, together with their common binding partner Mlx, have emerged as key mediators of intracellular glucose sensing. By regulating target genes involved in glycolysis and lipogenesis, they mediate metabolic adaptation to changing glucose levels. As disturbed glucose homeostasis plays a central role in human metabolic diseases and as cancer cells often display altered glucose metabolism, better understanding of cellular glucose sensing will likely uncover new therapeutic opportunities. Here we review the regulation, function and evolutionary conservation of the ChREBP/MondoA-Mlx glucose sensing system and discuss possible directions for future research. (C) 2012 Elsevier Ltd. All rights reserved.

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收藏

页码：640 / 647

页数：8

相关论文

共 121 条

[1] Hepatocyte nuclear factor-4α contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase [J].

Adamson, Aaron W. ;

Suchankova, Gabriela ;

Rufo, Caterina ;

Nakamura, Manabu T. ;

Teran-Garcia, Margarita ;

Clarke, Steven D. ;

Gettys, Thomas W. .

BIOCHEMICAL JOURNAL, 2006, 399 :285-295

[2] Overlapping Roles of the Glucose-Responsive Genes, S14 and S14R, in Hepatic Lipogenesis [J].

Aipoalani, Derrick L. ;

O'Callaghan, Brennon L. ;

Mashek, Douglas G. ;

Mariash, Cary N. ;

Towle, Howard C. .

ENDOCRINOLOGY, 2010, 151 (05) :2071-2077

[3]

Arden C, 2012, BIOCH J

[4] Mix, a novel max-like BHLHZip protein that interacts with the max network of transcription factors [J].

Billin, AN ;

Eilers, AL ;

Queva, C ;

Ayer, DE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (51) :36344-36350

[5] MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a Max-like network [J].

Billin, AN ;

Eilers, AL ;

Coulter, KL ;

Logan, JS ;

Ayer, DE .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (23) :8845-8854

[6] Positional cloning of the combined hyperlipidemia gene Hyplip1 [J].

Bodnar, JS ;

Chatterjee, A ;

Castellani, LW ;

Ross, DA ;

Ohmen, J ;

Cavalcoli, J ;

Wu, CY ;

Dains, KM ;

Catanese, J ;

Chu, M ;

Sheth, SS ;

Charugundla, K ;

Demant, P ;

West, DB ;

de Jong, P ;

Lusis, AJ .

NATURE GENETICS, 2002, 30 (01) :110-116

[7] ChREBP Mediates Glucose Repression of Peroxisome Proliferator-activated Receptor α Expression in Pancreatic β-Cells [J].

Boergesen, Michael ;

Poulsen, Lars la Cour ;

Schmidt, Soren Fisker ;

Frigerio, Francesca ;

Maechler, Pierre ;

Mandrup, Susanne .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (15) :13214-13225

[8] Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice [J].

Bricambert, Julien ;

Miranda, Jonatan ;

Benhamed, Fadila ;

Postic, Jean Girard Catherine ;

Dentin, Renaud .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (12) :4316-4331

[9] Carbohydrate-response element-binding protein deletion alters substrate utilization producing an energy-deficient liver [J].

Burgess, Shawn C. ;

Iizuka, Katsumi ;

Jeoung, Nam Ho ;

Harris, Robert A. ;

Kashiwaya, Yoshihiro ;

Veech, Richard L. ;

Kitazume, Tatsuya ;

Uyeda, Kosaku .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (03) :1670-1678

[10] cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4α, and CBP [J].

Burke, Susan J. ;

Collier, J. Jason ;

Scott, Donald K. .

FASEB JOURNAL, 2009, 23 (09) :2855-2865

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