Monte Carlo simulation of the enantioseparation process

被引：4

作者：

Bustos, V. A. ^{[1
]}

Acosta, G. ^{[2
]}

Gomez, M. R. ^{[2
]}

Pereyra, V. D. ^{[1
]}

机构：

[1] Consejo Nacl Invest Cient & Tecn, Inst Fis Aplicada INFAP, Dept Fis, RA-1033 Buenos Aires, DF, Argentina

[2] Univ Natl San Luis, CONICET, Inst Quim San Luis INQUISAL, Dept Farm, RA-5700 San Luis, Argentina

来源：

PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS | 2012年 / 391卷 / 18期

关键词：

Electrophoresis; Monte Carlo simulation; Enantiomers separation; CAPILLARY-ZONE-ELECTROPHORESIS; CHIRAL SEPARATION; THEORETICAL ASPECTS; BETA-CYCLODEXTRIN; STATIONARY-PHASE; CHROMATOGRAPHY; LIQUID; MODEL; ELECTROCHROMATOGRAPHY; ENANTIOMERS;

D O I：

10.1016/j.physa.2012.04.004

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

By means of Monte Carlo simulation, a study of enantioseparation by capillary electrophoresis has been carried out. A simplified system consisting of two enantiomers S (R) and a selector chiral C, which reacts with the enantiomers to form complexes RC (SC), has been considered. The dependence of Delta mu (enantioseparation) with the concentration of chiral selector and with temperature have been analyzed by simulation. The effect of the binding constant and the charge of the complexes are also analyzed. The results are qualitatively satisfactory, despite the simplicity of the model. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：4389 / 4396

页数：8

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