Targeting CCL2/CCR2 in Tumor-Infiltrating Macrophages: A Tool Emerging Out of the Box Against Hepatocellular Carcinoma

被引：15
作者：
Avila, Matias A. [1 ,2 ,3 ]
Berasain, Carmen [1 ,2 ,3 ]
机构：
[1] Univ Navarra, Hepatol Program, Ctr Invest Med Aplicada, Avda Pio XII 55, Pamplona 31008, Spain
[2] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
[3] Inst Invest Sanitarias Navarra, Inst Invest Sanitaria Navarra, Pamplona, Spain
来源：
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY | 2019年 / 7卷 / 02期
关键词：
D O I：
10.1016/j.jcmgh.2018.11.002
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
引用
收藏
页码：293 / 294
页数：2
相关论文
共 6 条
[1]   The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers [J].
Bartneck, Matthias ;
Schrammen, Peter L. ;
Moeckel, Diana ;
Govaere, Olivier ;
Liepelt, Anke ;
Krenkel, Oliver ;
Ergen, Can ;
McCain, Misti Vanette ;
Eulberg, Dirk ;
Luedde, Tom ;
Trautwein, Christian ;
Kiessling, Fabian ;
Reeves, Helen ;
Lammers, Twan ;
Tacke, Frank .
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2019, 7 (02) :371-390
[2]   CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis [J].
Ehling, Josef ;
Bartneck, Matthias ;
Wei, Xiao ;
Gremse, Felix ;
Fech, Viktor ;
Moeckel, Diana ;
Baeck, Christer ;
Hittatiya, Kanishka ;
Eulberg, Dirk ;
Luedde, Tom ;
Kiessling, Fabian ;
Trautwein, Christian ;
Lammers, Twan ;
Tacke, Frank .
GUT, 2014, 63 (12) :1960-1971
[3]   Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma [J].
Gerbes, Alexander ;
Zoulim, Fabien ;
Tilg, Herbert ;
Dufour, Jean-Francois ;
Bruix, Jordi ;
Paradis, Valerie ;
Salem, Riad ;
Peck-Radosavljevic, Markus ;
Galle, Peter R. ;
Greten, Tim F. ;
Nault, Jean-Charles ;
Avila, Matias A. .
GUT, 2018, 67 (02) :380-388
[4]   Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma [J].
Li, Xiaoguang ;
Yao, Wenbo ;
Yuan, Ya ;
Chen, Peizhan ;
Li, Bin ;
Li, Jingquan ;
Chu, Ruiai ;
Song, Haiyun ;
Xie, Dong ;
Jiang, Xiaoqing ;
Wang, Hui .
GUT, 2017, 66 (01) :157-167
[5]   Cenicriviroc for the treatment of non-alcoholic steatohepatitis and liver fibrosis [J].
Tacke, Frank .
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2018, 27 (03) :301-311
[6]   Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model [J].
Teng, Kun-Yu ;
Han, Jianfeng ;
Zhang, Xiaoli ;
Hsu, Shu-Hao ;
He, Shun ;
Wani, Nissar A. ;
Barajas, Juan M. ;
Snyder, Linda A. ;
Frankel, Wendy L. ;
Caligiuri, Michael A. ;
Jacob, Samson T. ;
Yu, Jianhua ;
Ghoshal, Kalpana .
MOLECULAR CANCER THERAPEUTICS, 2017, 16 (02) :312-322
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