Clinicopathological Significance and Diagnostic Accuracy of c-MET Expression by Immunohistochemistry in Gastric Cancer: A Meta-Analysis

被引:10
作者
Pyo, Jung-Soo [1 ]
Kang, Guhyun [2 ]
Cho, Hyunjin [3 ]
机构
[1] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Pathol, Seoul, South Korea
[2] Inje Univ, Sanggye Paik Hosp, Dept Pathol, Seoul, South Korea
[3] Inje Univ, Sanggye Paik Hosp, Dept Surg, 1342 Dongil Ro, Seoul 01757, South Korea
关键词
Stomach neoplasms; c-MET; Immunohistochemistry; Meta-analysis; Diagnostic test accuracy review; GROWTH-FACTOR RECEPTOR; PROGNOSTIC-SIGNIFICANCE; E-CADHERIN; TUMOR PROGRESSION; POOR-PROGNOSIS; OVEREXPRESSION; AMPLIFICATION; CARCINOMA; HER2; ASSOCIATION;
D O I
10.5230/jgc.2016.16.3.141
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: The aim of the present study was to elucidate the clinicopathological significance and diagnostic accuracy of immunohistochemistry (IHC) for determining the mesenchymal epidermal transition (c-MET) expression in patients with gastric cancer (GC). Materials and Methods: The present meta-analysis investigated the correlation between c-MET expression as determined by IHC and the clinicopathological parameters in 8,395 GC patients from 37 studies that satisfied the eligibility criteria. In addition, a concordance analysis was performed between c-MET expression as determined by IHC and c-MET amplification, and the diagnostic test accuracy was reviewed. Results: The estimated rate of c-MET overexpression was 0.403 (95% confidence interval [CI], 0.327 +/- 0.484) and it was significantly correlated with male patients, poor differentiation, lymph node metastasis, higher TNM stage, and human epidermal growth factor receptor 2 (HER2) positivity in IHC analysis. There was a significant correlation between c-MET expression and worse overall survival rate (hazard ratio, 1.588; 95% CI, 1.266 +/- 1.992). The concordance rates between c-MET expression and c-MET amplification were 0.967 (95% CI, 0.916 +/- 0.987) and 0.270 (95% CI, 0.173 +/- 0.395) for cases with non-overexpressed and overexpressed c-MET, respectively. In the diagnostic test accuracy review, the pooled sensitivity and specificity were 0.56 (95% CI, 0.50 +/- 0.63) and 0.79 (95% CI, 0.77 +/- 0.81), respectively. Conclusions: The c-MET overexpression as determined by IHC was significantly correlated with aggressive tumor behavior and positive IHC status for HER2 in patients with GC. In addition, the c-MET expression status could be useful in the screening of c-MET amplification in patients with GC.
引用
收藏
页码:141 / 151
页数:11
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