Clinicopathological Significance and Diagnostic Accuracy of c-MET Expression by Immunohistochemistry in Gastric Cancer: A Meta-Analysis

被引:10
作者
Pyo, Jung-Soo [1 ]
Kang, Guhyun [2 ]
Cho, Hyunjin [3 ]
机构
[1] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Pathol, Seoul, South Korea
[2] Inje Univ, Sanggye Paik Hosp, Dept Pathol, Seoul, South Korea
[3] Inje Univ, Sanggye Paik Hosp, Dept Surg, 1342 Dongil Ro, Seoul 01757, South Korea
关键词
Stomach neoplasms; c-MET; Immunohistochemistry; Meta-analysis; Diagnostic test accuracy review; GROWTH-FACTOR RECEPTOR; PROGNOSTIC-SIGNIFICANCE; E-CADHERIN; TUMOR PROGRESSION; POOR-PROGNOSIS; OVEREXPRESSION; AMPLIFICATION; CARCINOMA; HER2; ASSOCIATION;
D O I
10.5230/jgc.2016.16.3.141
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: The aim of the present study was to elucidate the clinicopathological significance and diagnostic accuracy of immunohistochemistry (IHC) for determining the mesenchymal epidermal transition (c-MET) expression in patients with gastric cancer (GC). Materials and Methods: The present meta-analysis investigated the correlation between c-MET expression as determined by IHC and the clinicopathological parameters in 8,395 GC patients from 37 studies that satisfied the eligibility criteria. In addition, a concordance analysis was performed between c-MET expression as determined by IHC and c-MET amplification, and the diagnostic test accuracy was reviewed. Results: The estimated rate of c-MET overexpression was 0.403 (95% confidence interval [CI], 0.327 +/- 0.484) and it was significantly correlated with male patients, poor differentiation, lymph node metastasis, higher TNM stage, and human epidermal growth factor receptor 2 (HER2) positivity in IHC analysis. There was a significant correlation between c-MET expression and worse overall survival rate (hazard ratio, 1.588; 95% CI, 1.266 +/- 1.992). The concordance rates between c-MET expression and c-MET amplification were 0.967 (95% CI, 0.916 +/- 0.987) and 0.270 (95% CI, 0.173 +/- 0.395) for cases with non-overexpressed and overexpressed c-MET, respectively. In the diagnostic test accuracy review, the pooled sensitivity and specificity were 0.56 (95% CI, 0.50 +/- 0.63) and 0.79 (95% CI, 0.77 +/- 0.81), respectively. Conclusions: The c-MET overexpression as determined by IHC was significantly correlated with aggressive tumor behavior and positive IHC status for HER2 in patients with GC. In addition, the c-MET expression status could be useful in the screening of c-MET amplification in patients with GC.
引用
收藏
页码:141 / 151
页数:11
相关论文
共 62 条
[21]   Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world [J].
Kamangar, Farin ;
Dores, Graca M. ;
Anderson, William F. .
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (14) :2137-2150
[22]   Tetraspanin CD151 expression associated with prognosis for patients with advanced gastric cancer [J].
Kang, Byung Woog ;
Lee, Dakeun ;
Chung, Ho Young ;
Han, Jae Ho ;
Kim, Young-Bae .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2013, 139 (11) :1835-1843
[23]   Amplification and overexpression of c-met gene in Epstein-Barr virus-associated gastric carcinomas [J].
Kijima, Y ;
Hokita, S ;
Yoshinaka, H ;
Itoh, T ;
Koriyama, C ;
Eizuru, Y ;
Akiba, S ;
Aikou, T .
ONCOLOGY, 2002, 62 (01) :60-65
[24]   Constitutive phosphorylation of the FOXO1A transcription factor as a prognostic variable in gastric cancer [J].
Kim, Ji Hun ;
Kim, Min Kyu ;
Lee, Hee Eun ;
Cho, Sung Jin ;
Cho, Yu Jin ;
Lee, Byung Lan ;
Lee, Hye Seung ;
Nam, Seon Young ;
Lee, Jae-Seon ;
Kim, Woo Ho .
MODERN PATHOLOGY, 2007, 20 (08) :835-842
[25]   Association of amphiregulin with the cetuximab sensitivity of gastric cancer cell lines [J].
Kneissl, Julia ;
Keller, Simone ;
Lorber, Thomas ;
Heindl, Stefan ;
Keller, Gisela ;
Drexler, Ingo ;
Hapfelmeier, Alexander ;
Hoefler, Heinz ;
Luber, Birgit .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2012, 41 (02) :733-744
[26]   Increased MACC1 expression indicates a poor prognosis independent of MET expression in gastric adenocarcinoma [J].
Koh, Young Wha ;
Hur, Hoon ;
Lee, Dakeun .
PATHOLOGY RESEARCH AND PRACTICE, 2016, 212 (02) :93-100
[27]   p53 mutation pattern and expression of c-erbB2 and c-met in gastric cancer -: Relation to histological subtypes, Helicobacter pylori infection, and prognosis [J].
Kubicka, S ;
Claas, C ;
Staab, S ;
Kühnel, F ;
Zender, L ;
Trautwein, C ;
Wagner, S ;
Rudolph, KL ;
Manns, M .
DIGESTIVE DISEASES AND SCIENCES, 2002, 47 (01) :114-121
[28]   Comprehensive analyses using next-generation sequencing and immunohistochemistry enable precise treatment in advanced gastric cancer [J].
Kuboki, Y. ;
Yamashita, S. ;
Niwa, T. ;
Ushijima, T. ;
Nagatsuma, A. ;
Kuwata, T. ;
Yoshino, T. ;
Doi, T. ;
Ochiai, A. ;
Ohtsu, A. .
ANNALS OF ONCOLOGY, 2016, 27 (01) :127-133
[29]   Prognostic Impact of Major Receptor Tyrosine Kinase Expression in Gastric Cancer [J].
Kurokawa, Yukinori ;
Matsuura, Nariaki ;
Kawabata, Ryohei ;
Nishikawa, Kazuhiro ;
Ebisui, Chikara ;
Yokoyama, Yuhki ;
Shaker, Mohammed Nouri ;
Hamakawa, Takuya ;
Takahashi, Tsuyoshi ;
Takiguchi, Shuji ;
Mori, Masaki ;
Doki, Yuichiro .
ANNALS OF SURGICAL ONCOLOGY, 2014, 21 :S584-S590
[30]   Impact of MET amplification on gastric cancer: Possible roles as a novel prognostic marker and a potential therapeutic target [J].
Lee, Jeeyun ;
Seo, Jin Won ;
Jun, Hyun Jung ;
Ki, Chang-Seok ;
Park, Se Hoon ;
Park, Young Suk ;
Lim, Ho Yeong ;
Choi, Min Gew ;
Bae, Jae Moon ;
Sohn, Tae Sung ;
Noh, Jae Hyung ;
Kim, Sung ;
Jang, Hey-Lim ;
Kim, Ji-Youn ;
Kim, Kyoung-Mee ;
Kang, Won Ki ;
Park, Joon Oh .
ONCOLOGY REPORTS, 2011, 25 (06) :1517-1524