Shedding light on the cell biology of extracellular vesicles

被引：5663

作者：

van Niel, Guillaume ^{[1
]}

D'Angelo, Gisela ^{[2
]}

Raposo, Graca ^{[2
]}

机构：

[1] INSERM, U895, Ctr Psychiat & Neurosci, F-75014 Paris, France

[2] Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR144,Struct & Membrane Compartments, F-75005 Paris, France

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2018年 / 19卷 / 04期

关键词：

MHC CLASS-II; EXOSOME RELEASE; PLASMA-MEMBRANE; DENDRITIC CELLS; MULTIVESICULAR BODIES; IN-VIVO; RETICULOCYTE MATURATION; LYSOSOMAL DEGRADATION; MEDIATED ENDOCYTOSIS; TRANSFERRIN RECEPTOR;

D O I：

10.1038/nrm.2017.125

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising exosomes and microvesicles, which originate from the endosomal system or which are shed from the plasma membrane, respectively. They are present in biological fluids and are involved in multiple physiological and pathological processes. Extracellular vesicles are now considered as an additional mechanism for intercellular communication, allowing cells to exchange proteins, lipids and genetic material. Knowledge of the cellular processes that govern extracellular vesicle biology is essential to shed light on the physiological and pathological functions of these vesicles as well as on clinical applications involving their use and/ or analysis. However, in this expanding field, much remains unknown regarding the origin, biogenesis, secretion, targeting and fate of these vesicles.

引用

页码：213 / 228

页数：16

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