Cryotherapy for local recurrent dermatofibrosarcoma protuberans: Experience in 19 patients

被引：11

作者：

Xu Jiongyuan ^{[1
]}

Li Jialiang ^{[1
,2
]}

Zhou Xulong ^{[2
]}

Zeng Jianying ^{[1
,2
]}

Yao Fei ^{[1
,2
]}

Wang Yuan ^{[1
,2
]}

Mu Feng ^{[1
,2
]}

Niu Lizhi ^{[1
,2
]}

Chen Jibing ^{[1
,2
]}

Liu Jianguo ^{[1
,2
]}

Xu Kecheng ^{[1
,2
]}

机构：

[1] Jinan Univ, Sch Med, Fuda Canc Hosp, Guangzhou 510665, Guangdong, Peoples R China

[2] Fuda Inst Cryosurg Canc, Guangzhou 510665, Guangdong, Peoples R China

来源：

CRYOBIOLOGY | 2014年 / 68卷 / 01期

关键词：

Dermatofibrosarcoma protuberans; Cryoablation; Progression-free survival; Recurrence rate; MOHS MICROGRAPHIC SURGERY; TRIPLE-FREEZE PROTOCOLS; TIBET PIG MODEL; CRYOABLATION; ABLATION; NECK; HEAD; CRYOSURGERY; TUMORS; PAIN;

D O I：

10.1016/j.cryobiol.2014.01.009

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive, cutaneous, malignant tumor characterized by a high propensity for local relapse. Wide and deep local excision with reconstructive surgery is the current standard therapy for DFSP, with a local recurrence rate (LRR) of nearly 40%. In this study, we cured 19 patients with local recurrence of DFSP with 39 sessions of percutaneous cryoablation performed between July 2004 and August 2008. The LRRs after one, two and three cryosurgery sessions per patient were 68%, 54% and 0%, respectively. Moreover, the LRR did not differ with tumor location or size. Furthermore, all patients had a progression-free survival of >5 years. Only minor complications such as fever, local edema, mild nerve injury and local pain occurred, and were resolved within 1 week with symptomatic treatment. In our experience, percutaneous cryoablation is a relatively safe and efficient technique for the treatment of local recurrence of DFSPs. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：134 / 138

页数：5

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