Polμ Deficiency Increases Resistance to Oxidative Damage and Delays Liver Aging

被引：6

作者：

Escudero, Beatriz ^{[1
,2
]}

Lucas, Daniel ^{[2
]}

Albo, Carmen ^{[1
]}

Dhup, Suveera ^{[1
]}

Bacher, Jeff W. ^{[3
]}

Sanchez-Munoz, Aranzazu ^{[4
]}

Fernandez, Margarita ^{[4
]}

Rivera-Torres, Jose ^{[5
]}

Carmona, Rosa M. ^{[1
,2
]}

Fuster, Encarnacio ^{[6
]}

Carreiro, Candelas ^{[1
]}

Bernad, Raquel ^{[2
]}

Gonzales, Manuel A. ^{[1
,2
]}

Andres, Vicente ^{[5
]}

Blanco, Luis ^{[7
]}

Roche, Enrique ^{[6
,8
]}

Fabregat, Isabel ^{[9
]}

Samper, Enrique ^{[1
,2
]}

Bernad, Antonio ^{[1
,2
]}

机构：

[1] CNIC, Dept Cardiol Regenerat, Madrid, Spain

[2] Campus Univ Auto noma Madrid, CSIC, Ctr Nacl Biotecnol, Dept Inmunol & Oncol, Madrid, Spain

[3] Promega Corp, Genet Anal Grp, Madison, WI USA

[4] Univ Complutense, Dept Bioquim & Biol Mol 2, E-28040 Madrid, Spain

[5] Ctr Nacl Invest Cardiovasc, Dept Epidemiol Aterotrombosis & Imagen, Madrid, Spain

[6] Miguel Hernandez Univ, Inst Bioengn, Elche, Alicante, Spain

[7] CSIC, Ctr Biol Mol Severo Ochoa, Canto Blanco, Madrid, Spain

[8] CIBERobn CB12 03 30038 Inst Salud Carlos, Madrid, Spain

[9] Hosp Llobregat, Bellvitge Biomed Res Inst IDIBELL, Barcelona, Spain

来源：

PLOS ONE | 2014年 / 9卷 / 04期

关键词：

DNA-POLYMERASE-MU; STRAND BREAK REPAIR; PATHWAY; CANCER; CELLS; MECHANISMS; LONGEVITY; DEFINES; HEALTH; ROLES;

D O I：

10.1371/journal.pone.0093074

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

pol mu an error- prone PoIX polymerase that contributes to classical NHEJ DNA repair. Mice lacking Pol mu (Pol mu (-/-)) show altered hematopoiesis homeostasis Pol mu 2/ 2 mice have increased learning capacity at old ages, suggesting delayed brain aging. Here we investigated the effect of Pol mu 2/ 2 deficiency on liver aging. We found that old Pol mu (-/-) mice (> 20 month) have greater liver regenerative capacity compared with wt animals. Old Pol mu (-/-) liver showed reduced genomic instability and increased apoptosis resistance. However, Pol mu (-/-) mice did not show an extended life span and other organs ( e. g., heart) aged normally. Our results suggest that Pol mu deficiency activates transcriptional networks that reduce constitutive apoptosis, leading to enhanced liver repair at old age.

引用

页数：11

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