Rhodamine-propargylic esters for detection of mitochondrial hydrogen sulfide in living cells

被引：30

作者：

Chen, Xi ^{[1
,2
]}

Wu, Shuqi ^{[1
,2
]}

Han, Jiahuai ^{[3
,4
]}

Han, Shoufa ^{[1
,2
]}

机构：

[1] Xiamen Univ, Dept Biol Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China

[3] Xiamen Univ, State Key Lab Cellular Stress Biol, Xiamen 361005, Peoples R China

[4] Xiamen Univ, Sch Life Sci, Xiamen 361005, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 19期

关键词：

Rhodamine; Propargylic ester; Hydrogen sulfide; Mitochondria; Bioimaging; Flow cytometry; RATIOMETRIC FLUORESCENT-PROBE;

D O I：

10.1016/j.bmcl.2013.07.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Flow cytometric detection of mitochondrial H2S was achieved with propargylic esters of rhodamine B which selectively react with H2S via cationic rhodamine-moiety directed thiolysis of the propargylic esters to give nonfluorescent rhodamine thio-spirolactone. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：5295 / 5299

页数：5

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