Zinc-gold cooperative catalysis for the direct alkynylation of benzofurans

被引：47

作者：

Li, Yifan ^{[1
]}

Waser, Jerome ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Catalysis & Organ Synth, EPFL SB ISIC LCSO, CH-1015 Lausanne, Switzerland

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 9卷

关键词：

alkynylation; benzofurans; cooperative catalysis; direct functionalization; gold catalysis; hypervalent iodine; HYPERVALENT IODINE REAGENTS; BENZIODOXOLONES; ACTIVATION; THIOPHENES;

D O I：

10.3762/bjoc.9.204

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct alkynylation of benzofurans was achieved for the first time using the hypervalent iodine reagent 1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX) based on the cooperative effect between a gold catalyst and a zinc Lewis acid. High selectivity was observed for C2-alkynylation of benzofurans substituted with alkyl, aryl, halogen and ether groups. The reaction was also successful in the case of the more complex drug 8-methoxypsoralen (8-MOP).

引用

页码：1763 / 1767

页数：5

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