Three new cytotoxic sesquiterpenoids from Solanum lyratum

In our continuing effort to discover more new cytotoxic sesquiterpenoid from Solanum lyratum collected from different districts of China, three new sesquiterpenoids, attributable to eudesmane-type (1, named solajiangxin D) and vetispirane-type (2-3, named solajiangxins E and 2-hydroxysolajiangxin E), respectively, were isolated. Their structures were elucidated on the basis of integrated spectroscopic techniques, mainly HR-FABMS, 1D and 2D NMR (H-1-H-1 COSY, HMQC, HMBC and ROESY). In vitro, compounds 1-3 were found to show significant cytotoxicities against three human cancer lines (P-388, HONE-1, and HT-29), and gave ED50 values in the range 2.1-3.7 mu g/ml. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.