Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography

被引：200
作者：
Tokayer, Jason [1 ]
Jia, Yali [2 ]
Dhalla, Al-Hafeez [2 ,3 ,4 ,5 ]
Huang, David [2 ]
机构：
[1] Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA
[2] Oregon Hlth & Sci Univ, Casey Eye Inst, Portland, OR 97239 USA
[3] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[4] MIT, Elect Res Lab, Cambridge, MA 02139 USA
[5] Tufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2013年 / 4卷 / 10期
关键词：
IN-VIVO; DOPPLER TOMOGRAPHY; HIGH-SPEED; RETINAL CAPILLARIES; POSTERIOR EYE; HUMAN SKIN; RESOLUTION; OCT; MICROVASCULATURE; VISUALIZATION;
D O I：
10.1364/BOE.4.001909
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was recently developed as a method for imaging blood flow in the human retina without the use of phase information. In order to enable absolute blood velocity quantification, in vitro phantom experiments are performed to correlate the SSADA signal at multiple time scales with various preset velocities. A linear model relating SSADA measurements to absolute flow velocities is derived using the phantom data. The operating range for the linear model is discussed along with its implication for velocity quantification with SSADA in a clinical setting. (c) 2013 Optical Society of America
引用
收藏
页码：1909 / 1924
页数：16
相关论文
共 56 条
[1]   In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography [J].
An, Lin ;
Wang, Ruikang K. .
OPTICS EXPRESS, 2008, 16 (15) :11438-11452
[2]   Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT [J].
Baumann, Bernhard ;
Potsaid, Benjamin ;
Kraus, Martin F. ;
Liu, Jonathan J. ;
Huang, David ;
Hornegger, Joachim ;
Cable, Alex E. ;
Duker, Jay S. ;
Fujimoto, James G. .
BIOMEDICAL OPTICS EXPRESS, 2011, 2 (06) :1539-1552
[3]   Doppler flow imaging of cytoplasmic streaming using spectral domain phase microscopy [J].
Choma, Michael A. ;
Ellerbee, Audrey K. ;
Yazdanfar, Siavash ;
Izatt, Joseph A. .
JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (02)
[4]   Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography [J].
Fingler, Jeff ;
Schwartz, Dan ;
Yang, Changhuei ;
Fraser, Scott E. .
OPTICS EXPRESS, 2007, 15 (20) :12636-12653
[5]   The impact of ocular blood flow in glaucoma [J].
Flammer, J ;
Orgül, S ;
Costa, VP ;
Orzalesi, N ;
Krieglstein, GK ;
Serra, LM ;
Renard, JP ;
Stefánsson, E .
PROGRESS IN RETINAL AND EYE RESEARCH, 2002, 21 (04) :359-393
[6]   Observation of Erythrocyte Dynamics in the Retinal Capillaries and Choriocapillaris Using ICG-Loaded Erythrocyte Ghost Cells [J].
Flower, Robert ;
Peiretti, Enrico ;
Magnani, Mauro ;
Rossi, Luigia ;
Serafini, Sonja ;
Gryczynski, Zygmunt ;
Gryczynski, Ignacy .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2008, 49 (12) :5510-5516
[7]   A hemodynamic model of the pathogenesis of age-related macular degeneration [J].
Friedman, E .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1997, 124 (05) :677-682
[8]   Scanning protocols dedicated to smart velocity ranging in Spectral OCT [J].
Grulkowski, Ireneusz ;
Gorczynska, Iwona ;
Szkulmowski, Maciej ;
Szlag, Daniel ;
Szkulmowska, Anna ;
Leitgeb, Rainer A. ;
Kowalczyk, Andrzej ;
Wojtkowski, Maciej .
OPTICS EXPRESS, 2009, 17 (26) :23736-23754
[9]   OPTICAL COHERENCE TOMOGRAPHY OF THE HUMAN RETINA [J].
HEE, MR ;
IZATT, JA ;
SWANSON, EA ;
HUANG, D ;
SCHUMAN, JS ;
LIN, CP ;
PULIAFITO, CA ;
FUJIMOTO, JG .
ARCHIVES OF OPHTHALMOLOGY, 1995, 113 (03) :325-332
[10]   Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary beds using speckle variance optical coherence tomography [J].
Hendargo, Hansford C. ;
Estrada, Rolando ;
Chiu, Stephanie J. ;
Tomasi, Carlo ;
Farsiu, Sina ;
Izatt, Joseph A. .
BIOMEDICAL OPTICS EXPRESS, 2013, 4 (06) :803-821
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