Oxidative Trifluoromethylation of Unactivated Olefins: An Efficient and Practical Synthesis of α-Trifluoromethyl-Substituted Ketones

被引：272

作者：

Deb, Arghya ^{[1
]}

Manna, Srimanta ^{[1
]}

Modak, Atanu ^{[1
]}

Patra, Tuhin ^{[1
]}

Maity, Soham ^{[1
]}

Maiti, Debabrata ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 37期

关键词：

ketones; Langlois reagent; olefins; synthetic methods; trifluoromethylation; SILYL ENOL ETHERS; RADICAL TRIFLUOROMETHYLATION; MEDICINAL CHEMISTRY; CARBONYL-COMPOUNDS; SODIUM TRIFLUOROMETHANESULFINATE; ASYMMETRIC TRIFLUOROMETHYLATION; CATALYZED TRIFLUOROMETHYLATION; MEDIATED TRIFLUOROMETHYLATION; PHOTOREDOX CATALYSIS; AROMATIC-COMPOUNDS;

D O I：

10.1002/anie.201303576

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An economical approach to α-CF3-substituted ketones, which are important intermediates in synthetic and medicinal chemistry, employs olefins and the readily available Langlois reagent (CF3SO 2Na). The reaction is operationally simple, proceeds at room temperature, and exhibits an excellent tolerance toward a wide variety of functional groups. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9747 / 9750

页数：4

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