Monocyte Subsets Are Differently Associated with Infarct Size, Left Ventricular Function, and the Formation of a Potentially Arrhythmogenic Scar in Patients with Acute Myocardial Infarction

被引：7

作者：

Bosch, Xavier ^{[1
,2
]}

Jauregui, Beatriz ^{[1
,2
,3
]}

Villamor, Neus ^{[2
,4
]}

Morales-Ruiz, Manuel ^{[2
,5
,6
]}

Ortiz-Perez, Jose T. ^{[1
,2
]}

Borras, Roger ^{[1
]}

Penela, Diego ^{[7
]}

Soto-Iglesias, David ^{[1
,3
]}

Perea, Rosario J. ^{[8
]}

Doltra, Ada ^{[1
]}

Prat-Gonzalez, Susana ^{[1
]}

Jimenez, Wladimiro ^{[5
,6
]}

Mira, Aurea ^{[2
,5
]}

Lasalvia, Luis ^{[9
]}

Berruezo, Antonio ^{[3
]}

机构：

[1] Univ Barcelona, Hosp Clin, Cardiovasc Inst, Dept Cardiol, Carrer Villarroel,170, Barcelona 08036, Spain

[2] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain

[3] Teknon Med Ctr, Inst Heart, Barcelona, Spain

[4] Univ Barcelona, Hosp Clin, Dept Pathol, Hematopathol Unit, Barcelona, Spain

[5] Univ Barcelona, Hosp Clin, Biochem & Mol Genet Dept, Barcelona, Spain

[6] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain

[7] Osped Guglielmo Saliceto, Dept Cardiol, Piacenza, Italy

[8] Univ Barcelona, Hosp Clin, Dept Radiol, Barcelona, Spain

[9] Siemens Healthcare Diagnost, New York, NY USA

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2020年 / 13卷 / 05期

关键词：

Monocytes; Myocardial infarction; Left ventricular function; Arrhythmogenic substrate; MAGNETIC-RESONANCE; HETEROGENEITY; TACHYCARDIA; MICE;

D O I：

10.1007/s12265-019-09944-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To investigate the role of classical (CLM, CD14(++)CD16(-)), intermediate (INTM, CD14(++)CD16(+)), and non-classical (Non-CLM, CD14(+)CD16(++)) monocytes in scar formation after ST-elevation myocardial infarction (STEMI), evaluated with cardiac magnetic resonance (CMR). One hundred two patients with a first STEMI had serial blood analyses after 1, 3, and 7 days. A CMR was performed at 7 days and 6 months, depicting scar core (CO), border zone (BZ), and the presence of BZ channels. CLM and INTM levels progressively decreased, correlated with the scar mass, CO, and BZ at 7 days and 6 months (p < 0.05), and inversely with left ventricular ejection fraction (LVEF,p < 0.01). Non-CLM levels gradually increased, correlated with BZ mass and the presence of BZ channels at 7 days and 6 months (p < 0.001).CLM and INTM are associated with infarct size and inversely with LVEF, whereas Non-CLM are associated with BZ mass and the presence of potentially arrhythmogenic substrate.

引用

页码：722 / 730

页数：9

共 21 条

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