Step emulsification in microfluidic droplet generation: mechanisms and structures

被引：54
作者：
Shi, Zhi [1 ]
Lai, Xiaochen [1 ]
Sun, Chengtao [1 ]
Zhang, Xingguo [1 ]
Zhang, Lei [1 ]
Pu, Zhihua [1 ]
Wang, Ridong [1 ]
Yu, Haixia [2 ]
Li, Dachao [1 ]
机构：
[1] Tianjin Univ, State Key Lab Precis Measuring Technol & Instrume, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Tianjin Key Lab Biomed Detecting Tech & Instrumen, Tianjin 300072, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 64期
基金：
中国国家自然科学基金;
关键词：
HIGH-THROUGHPUT PRODUCTION; ULTRA-HIGH-THROUGHPUT; IN-OIL EMULSIONS; MICROCHANNEL EMULSIFICATION; INTERFACIAL-TENSION; MULTIPLE EMULSIONS; ASPECT RATIO; SINGLE; SILICON; QUANTIFICATION;
D O I：
10.1039/d0cc03628e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The droplet-based microfluidic techniques have been applied widely in functional material synthesis and biomedical information measurements, wherein step emulsification as an integrated system combines the advantages of homogeneity and throughput in monodisperse droplet formation. This paper reviews the mechanisms and classical structures of step emulsification. In terms of droplet formation mechanisms, we describe the droplet size and detachment regimes related to the microchannel geometry. Distinguished by droplet formation, microfluidic step emulsification driven by interfacial tension and centrifugal step emulsification related to buoyancy are introduced respectively, including their improved structures for enhancing the droplet homogeneity and throughput. Finally, the perspectives about the developments of step emulsification in mechanisms, fabrications, and applications are discussed.
引用
收藏
页码：9056 / 9066
页数：11
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