PACAP38 in human models of primary headaches

被引：25
作者：
Ashina, Hakan [1 ]
Guo, Song [1 ]
Vollesen, Anne L. H. [1 ]
Ashina, Messoud [1 ]
机构：
[1] Univ Copenhagen, Fac Hlth & Med Sci, Rigshosp Glostrup, Dept Neurol,Danish Headache Ctr, Copenhagen, Denmark
来源：
JOURNAL OF HEADACHE AND PAIN | 2017年 / 18卷
关键词：
PACAP38; Human provocation models; Primary headaches; PAC(1); Migraine; CYCLASE-ACTIVATING POLYPEPTIDE; MIDDLE MENINGEAL ARTERY; MIGRAINE-LIKE ATTACKS; GENE-RELATED PEPTIDE; VASOACTIVE-INTESTINAL-PEPTIDE; MAST-CELL DEGRANULATION; HUMAN CEREBRAL-ARTERIES; BLOOD-BRAIN-BARRIER; MESSENGER-RNA; NERVE-FIBERS;
D O I：
10.1186/s10194-017-0821-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: To review the role of PACAP38 in human models of primary headaches, discuss possible mechanisms of PACAP38-induced migraine, and outline future directions. Discussion: Experimental studies have established PACAP38 as a potent pharmacological "trigger" molecule of migraine-like attacks. These studies have also revealed a heterogeneous PACAP38 migraine response in migraine without aura patients. In addition, findings from brain imaging studies have demonstrated neuronal and vascular changes in migraine patients both ictally and interictally after PACAP38 infusion. Conclusion: Human migraine models have shed light on the importance of PACAP38 in the pathophysiology of primary headaches. These studies have also pointed to the PAC(1) receptor and the PACAP38 molecule itself as target sites for drug testing. Future research should seek to understand the mechanisms underlying PACAP38-induced migraine. The results from an ongoing proof of concept randomized clinical trial may reveal the therapeutic potential of anti-PAC(1) receptor antibodies for migraine prevention.
引用
收藏
页数：9
相关论文
共 92 条
[1]   Glyceryl trinitrate triggers premonitory symptoms in migraineurs [J].
Afridi, SK ;
Kaube, H ;
Goadsby, PJ .
PAIN, 2004, 110 (03) :675-680
[2]   Neuronal PAC1 receptors mediate delayed activation and sensitization of trigeminocervical neurons: Relevance to migraine [J].
Akerman, Simon ;
Goadsby, Peter J. .
SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (308)
[3]  
Alder, 2017, ROB DEV PIP
[4]  
Amgen, 2000, EV BLOCK CGRP PREV P
[5]  
Amgen, STUD EV EFF SAF AMG
[6]   Change in brain network connectivity during PACAP38-induced migraine attacks A resting-state functional MRI study [J].
Amin, Faisal Mohammad ;
Hougaard, Anders ;
Magon, Stefano ;
Asghar, Mohammad Sohail ;
Ahmad, Nur Nabil ;
Rostrup, Egill ;
Sprenger, Till ;
Ashina, Messoud .
NEUROLOGY, 2016, 86 (02) :180-187
[7]   Measurement precision and biological variation of cranial arteries using automated analysis of 3 T magnetic resonance angiography [J].
Amin, Faisal Mohammad ;
Lundholm, Elisabet ;
Hougaard, Anders ;
Arngrim, Nanna ;
Wiinberg, Linda ;
de Koning, Patrick J. H. ;
Larsson, Henrik B. W. ;
Ashina, Messoud .
JOURNAL OF HEADACHE AND PAIN, 2014, 15
[8]   Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38 [J].
Amin, Faisal Mohammad ;
Hougaard, Anders ;
Schytz, Henrik W. ;
Asghar, Mohammad S. ;
Lundholm, Elisabet ;
Parvaiz, Arushma I. ;
de Koning, Patrick J. H. ;
Andersen, Malene R. ;
Larsson, Henrik B. W. ;
Fahrenkrug, Jan ;
Olesen, Jes ;
Ashina, Messoud .
BRAIN, 2014, 137 :779-794
[9]   The effect of sumatriptan on cephalic arteries: A 3T MR-angiography study in healthy volunteers [J].
Amin, Faisal Mohammad ;
Asghar, Mohammad Sohail ;
Ravneberg, Julie W. ;
de Koning, Patrick J. H. ;
Larsson, Henrik B. W. ;
Olesen, Jes ;
Ashina, Messoud .
CEPHALALGIA, 2013, 33 (12) :1009-1016
[10]   Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers [J].
Amin, Faisal Mohammad ;
Asghar, Mohammad Sohail ;
Guo, Song ;
Hougaard, Anders ;
Hansen, Adam Espe ;
Schytz, Henrik Winther ;
van der Geest, Rob J. ;
de Koning, Patrick J. H. ;
Larsson, Henrik B. W. ;
Olesen, Jes ;
Ashina, Messoud .
CEPHALALGIA, 2012, 32 (02) :140-149
12345678910