Glucose Oxidation and PQQ-Dependent Dehydrogenases in Gluconobacter oxydans

被引：39

作者：

Hoelscher, Tina ^{[2
]}

Schleyer, Ute ^{[1
]}

Merfort, Marcel ^{[1
]}

Bringer-Meyer, Stephanie ^{[1
]}

Goerisch, Helmut ^{[2
]}

Sahm, Hermann ^{[1
]}

机构：

[1] Forschungszentrum Julich, Inst Biotechnol 1, DE-52425 Julich, Germany

[2] Tech Univ Berlin, Inst Biotechnol, Fachgebiet Tech Biochem, Berlin, Germany

来源：

JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY | 2009年 / 16卷 / 1-2期

关键词：

Gluconobacter; 5-Keto-D-gluconate; PQQ-dependent dehydrogenases; Glucose oxidation; Quinoproteins; D-SORBITOL DEHYDROGENASE; PYRROLOQUINOLINE QUINONE; 5-KETO-D-GLUCONIC ACID; ESCHERICHIA-COLI; POLYOL DEHYDROGENASE; PROTON TRANSLOCATION; SUBOXYDANS IFO-3255; NUCLEOTIDE-SEQUENCE; PURIFICATION; BIOSYNTHESIS;

D O I：

10.1159/000142890

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Gluconobacter oxydans is famous for its rapid and incomplete oxidation of a wide range of sugars and sugar alcohols. The organism is known for its efficient oxidation of D-glucose to D-gluconate, which can be further oxidized to two different keto-D-gluconates, 2-keto-D-gluconate and 5-keto-D-gluconate, as well as 2,5-di-keto-D-gluconate. For this oxidation chain and for further oxidation reactions, G. oxydans possesses a high number of membrane-bound dehydrogenases. In this review, we focus on the dehydrogenases involved in D-glucose oxidation and the products formed during this process. As some of the involved dehydrogenases contain pyrroloquinoline quinone (PQQ) as a cofactor, also PQQ synthesis is reviewed. Finally, we will give an overview of further PQQ-dependent dehydrogenases and discuss their functions in G. oxydans ATCC 621H (DSM 2343). Copyright (c) 2008 S. Karger AG, Basel

引用

页码：6 / 13

页数：8

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