Impact of radiotherapy on microsurgical reconstruction of the head and neck

被引：27

作者：

Hohlweg-Majert, Bettina ^{[1
]}

Ristow, Oliver ^{[1
]}

Gust, Katharina ^{[1
]}

Kehl, Victoria ^{[2
]}

Wolff, Klaus-Dietrich ^{[3
]}

Pigorsch, Steffi ^{[4
]}

机构：

[1] Clin Oral Maxillofacial & Plast Surg, D-80333 Munich, Germany

[2] Tech Univ Munich, Inst Med Stat & Epidemiol, D-81675 Munich, Germany

[3] Tech Univ Munich, Dept Oral & Maxillofacial Surg, D-81675 Munich, Germany

[4] Tech Univ Munich, Dept Radiat Oncol, D-81675 Munich, Germany

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2012年 / 138卷 / 11期

关键词：

Microvascular reconstruction; Radiotherapy; Head and neck oncology; Free flap; FREE TISSUE TRANSFER; FREE-FLAP RECONSTRUCTION; SQUAMOUS-CELL CARCINOMA; DONOR-SITE SELECTION; RADIATION-THERAPY; UP-REGULATION; SURGERY; CANCER; IRRADIATION; COMPLICATIONS;

D O I：

10.1007/s00432-012-1263-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To examine tissue oxygenation and perfusion of free microvascular grafts after primary reconstruction, regarding outcome for patients received adjuvant radiotherapy and different types of grafts. Free microvascular grafts (n = 48) after primary reconstruction of the head and neck were examined for tissue oxygenation and perfusion over a period of 6 months. 28 patients received adjuvant radiotherapy. Using a laser doppler flowmetry combined with tissue spectroscopy of the Oxygen-to-see(A (R))-equipment (LEA Medizintechnik, Giessen), we were able to determine oxygen saturation, hemoglobin concentration, blood flow and blood flow velocity in the graft in each of two tissue depths (2, 8 mm). Different types of graft were compared. Comparison of irradiated and non-irradiated grafts showed significant differences in tissue perfusion and oxygenation. Results for all radiated radial and fibula flaps showed no significant (p > 0.05) differences for all reviewed parameters. However, it showed no dose-volume effect with impaired functionality was found for irradiated grafts. Mircovascular free tissue grafts show an increased perfusion and oxygenation after radiation compared to non-irradiated grafts.

引用

页码：1799 / 1811

页数：13

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