Impact of radiotherapy on microsurgical reconstruction of the head and neck

被引：27
作者：
Hohlweg-Majert, Bettina [1 ]
Ristow, Oliver [1 ]
Gust, Katharina [1 ]
Kehl, Victoria [2 ]
Wolff, Klaus-Dietrich [3 ]
Pigorsch, Steffi [4 ]
机构：
[1] Clin Oral Maxillofacial & Plast Surg, D-80333 Munich, Germany
[2] Tech Univ Munich, Inst Med Stat & Epidemiol, D-81675 Munich, Germany
[3] Tech Univ Munich, Dept Oral & Maxillofacial Surg, D-81675 Munich, Germany
[4] Tech Univ Munich, Dept Radiat Oncol, D-81675 Munich, Germany
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2012年 / 138卷 / 11期
关键词：
Microvascular reconstruction; Radiotherapy; Head and neck oncology; Free flap; FREE TISSUE TRANSFER; FREE-FLAP RECONSTRUCTION; SQUAMOUS-CELL CARCINOMA; DONOR-SITE SELECTION; RADIATION-THERAPY; UP-REGULATION; SURGERY; CANCER; IRRADIATION; COMPLICATIONS;
D O I：
10.1007/s00432-012-1263-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To examine tissue oxygenation and perfusion of free microvascular grafts after primary reconstruction, regarding outcome for patients received adjuvant radiotherapy and different types of grafts. Free microvascular grafts (n = 48) after primary reconstruction of the head and neck were examined for tissue oxygenation and perfusion over a period of 6 months. 28 patients received adjuvant radiotherapy. Using a laser doppler flowmetry combined with tissue spectroscopy of the Oxygen-to-see(A (R))-equipment (LEA Medizintechnik, Giessen), we were able to determine oxygen saturation, hemoglobin concentration, blood flow and blood flow velocity in the graft in each of two tissue depths (2, 8 mm). Different types of graft were compared. Comparison of irradiated and non-irradiated grafts showed significant differences in tissue perfusion and oxygenation. Results for all radiated radial and fibula flaps showed no significant (p > 0.05) differences for all reviewed parameters. However, it showed no dose-volume effect with impaired functionality was found for irradiated grafts. Mircovascular free tissue grafts show an increased perfusion and oxygenation after radiation compared to non-irradiated grafts.
引用
收藏
页码：1799 / 1811
页数：13
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