JN403, a nicotinic acetylcholine receptor alpha 7 selective agonist: Structure-activity relationship and in vitro and in vivo profile

被引：0
|
作者：
Nozulak, J. [1 ]
Feuerbach, D. [1 ]
Hoyer, D. [1 ]
Lingenhoehl, K. [1 ]
Olpe, H. -R. [1 ]
Vassout, A. [1 ]
Gentsch, C. [1 ]
Chaperon, F. [1 ]
McAllister, K. [1 ]
机构：
[1] Novartis Pharma AG, GDC Neurosci, Basel, Switzerland
来源：
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2008年 / 11卷
关键词：
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
引用
收藏
页码：265 / 266
页数：2
相关论文
共 50 条
  • [21] The alpha7 nicotinic acetylcholine receptor agonist PHA-543613 has antifibrotic activity in vivo in the scleroderma mouse model
    Stegemann, A.
    Luger, T. A.
    Bohm, M.
    EXPERIMENTAL DERMATOLOGY, 2019, 28 (03) : E32 - E33
  • [22] In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107
    Malysz, John
    Anderson, David J.
    Gronlien, Jens H.
    Ji, Jianguo
    Bunnelle, William H.
    Hakerud, Monika
    Thorin-Hagene, Kirten
    Ween, Hilde
    Helfrich, Rosalind
    Hu, Min
    Gubbins, Earl
    Gopalakrishnan, Sujatha
    Puttfarcken, Pamela S.
    Briggs, Clark A.
    Li, Jinhe
    Meyer, Michael D.
    Dyhring, Tino
    Ahring, Philip K.
    Nielsen, Elsebet O.
    Peters, Dan
    Timmermann, Daniel B.
    Gopalakrishnan, Murali
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 334 (03) : 863 - 874
  • [23] Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation
    Pismataro, Maria Chiara
    Horenstein, Nicole A.
    Stokes, Clare
    Quadri, Marta
    De Amici, Marco
    Papke, Roger L.
    Dallanoce, Clelia
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 205
  • [24] Molecular dissection of tropisetron, an α7 nicotinic acetylcholine receptor-selective partial agonist
    Papke, RL
    Schiff, HC
    Jack, BA
    Horenstein, NA
    NEUROSCIENCE LETTERS, 2005, 378 (03) : 140 - 144
  • [25] Alpha7 nicotinic acetylcholine receptor agonist improves survival during endotoxemia
    Chen, F.
    Cai, B.
    Dong, W.
    Deitch, E. A.
    Ulloa, L.
    SHOCK, 2008, 29 : 80 - 80
  • [26] Biomolecular recognition of antagonists by α7 nicotinic acetylcholine receptor: Antagonistic mechanism and structure-activity relationships studies
    Peng, Wei
    Ding, Fei
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 76 : 119 - 132
  • [27] Relationship between agonist structure and the nicotinic acetylcholine receptor channel opening rate constant
    Salamone, F
    Zhou, M
    Akk, G
    Auerbach, A
    BIOPHYSICAL JOURNAL, 1997, 72 (02) : TUP65 - TUP65
  • [28] EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors
    Prickaerts, Jos
    van Goethem, Nick P.
    Chesworth, Richard
    Shapiro, Gideon
    Boess, Frank G.
    Methfessel, Christoph
    Reneerkens, Olga A. H.
    Flood, Dorothy G.
    Hilt, Dana
    Gawryl, Maria
    Bertrand, Sonia
    Bertrand, Daniel
    Koenig, Gerhard
    NEUROPHARMACOLOGY, 2012, 62 (02) : 1099 - 1110
  • [29] ICH3, a selective alpha7 nicotinic acetylcholine receptor agonist, modulates adipocyte inflammation associated with obesity
    Scabia, G.
    Cancello, R.
    Dallanoce, C.
    Berger, S.
    Matera, C.
    Dattilo, A.
    Zulian, A.
    Barone, I
    Ceccarini, G.
    Santini, F.
    De Amici, M.
    Di Blasio, A. M.
    Maffei, M.
    JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2020, 43 (07) : 983 - 993
  • [30] Epibatidine: A nicotinic acetylcholine receptor agonist releases monoaminergic neurotransmitters: In vitro and in vivo evidence in rats
    Sacaan, AI
    Menzaghi, F
    Dunlop, JL
    Correa, LD
    Whelan, KT
    Lloyd, GK
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1996, 276 (02) : 509 - 515
12345