Synthesis and antimicrobial activity of some 2,5-disubstituted 1,3,4-oxadiazoles

4-Chloro aniline is condensed with methyl acrylate in presence of acetic acid to yield methyl-beta-(4-chloro methyl aniline)-propionate, which was further treated with hydrazine hydrate in presence of ethanol to obtain beta -alanine-N-(4-chloro methyl-phenyl) hydrazide, on cyclization with ethanolic potassium hydroxide and carbon disulphide gives 2-mercapto-5-(4-chloro methyl-anilino ethyl)-1,3,4-oxadiazole (1-4). These oxadiazoles on refluxing with Morpholine / Piperidine / Dimethylamine Diethylamine gave 2,5-disubstituted derivatives. Antimicrobial activity of these compounds was studied (5).