Synthesis and antimicrobial activity of some 2,5-disubstituted 1,3,4-oxadiazoles

被引：0

作者：

Honnalli, SS ^{[1
]}

Ronad, PM ^{[1
]}

Vijaybhasker, K ^{[1
]}

Hukkeri, VI ^{[1
]}

Kumar, R ^{[1
]}

机构：

[1] KLEs Coll Pharm, Dept Pharmaceut Chem, Vijayanagar 580031, Hubli, India

来源：

HETEROCYCLIC COMMUNICATIONS | 2005年 / 11卷 / 06期

关键词：

oxadiazole; propionate;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Chloro aniline is condensed with methyl acrylate in presence of acetic acid to yield methyl-beta-(4-chloro methyl aniline)-propionate, which was further treated with hydrazine hydrate in presence of ethanol to obtain beta -alanine-N-(4-chloro methyl-phenyl) hydrazide, on cyclization with ethanolic potassium hydroxide and carbon disulphide gives 2-mercapto-5-(4-chloro methyl-anilino ethyl)-1,3,4-oxadiazole (1-4). These oxadiazoles on refluxing with Morpholine / Piperidine / Dimethylamine Diethylamine gave 2,5-disubstituted derivatives. Antimicrobial activity of these compounds was studied (5).

引用

页码：505 / 508

页数：4

共 50 条

[1] Synthesis of some pyrazolylaldehyde N-isonicotinoyl hydrazones and 2,5-disubstituted 1,3,4-oxadiazoles as DNA photocleaving agents
M. Kumar
V. Kumar
V. Beniwal
Medicinal Chemistry Research, 2015, 24 : 2862 - 2870
[2] Synthesis of some pyrazolylaldehyde N-isonicotinoyl hydrazones and 2,5-disubstituted 1,3,4-oxadiazoles as DNA photocleaving agents
Kumar, M.
Kumar, V.
Beniwal, V.
MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (07) : 2862 - 2870
[3] Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes
Paidi, Karuna Raman
Kolli, Murali Krishna
Reddy, Eeda Koti
Pedakotla, Venkata Ramana
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2020, 56 (03) : 371 - 376
[4] Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes
Karuna Raman Paidi
Murali Krishna Kolli
Eeda Koti Reddy
Venkata Ramana Pedakotla
Chemistry of Heterocyclic Compounds, 2020, 56 : 371 - 376
[5] Syntheses and insecticidal activities of novel 2,5-disubstituted-1,3,4-oxadiazoles
Qian, XH
Zhang, R
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 1996, 67 (02) : 124 - 130
[6] Oxidative Cyclization of Isoniazid with Fluoroquinolones: Synthesis, Antibacterial and Antitubercular Activity of New 2,5-disubstituted-1,3,4-Oxadiazoles
Khan, Shah Alam
Ahuja, Priyanka
Husain, Asif
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2017, 64 (08) : 918 - 924
[7] Copper-Catalyzed One-Pot Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from Arylacetic Acids and Hydrazides via Dual Oxidation
Lekkala, Chinnari
Bodala, Varaprasad
Yettula, Kumari
Karasala, Bharat Kumar
Podugu, Rajitha Lakshmi
Vidavalur, Siddaiah
ACS OMEGA, 2022, : 27157 - 27163
[8] Novel 2,5-disubstituted-1,3,4-oxadiazoles as anti-inflammatory drugs
Durgashivaprasad, Ega
Mathew, Geetha
Sebastian, Sarine
Reddy, Manohar S. A.
Mudgal, Jayesh
Nampurath, Gopalan Kutty
INDIAN JOURNAL OF PHARMACOLOGY, 2014, 46 (05) : 521 - 526
[9] Design, Synthesis, Anticancer Activity and Molecular Docking Studies of 2,5-Disubstituted-1,3,4-Oxadiazoles Containing Benzirnidazole Moiety
Katikireddy, Ramamurthy
Kakkerla, Ramu
Krishna, M. P. S. Murali
Durgaiah, Gandamalla
Reddy, Y. N.
LETTERS IN ORGANIC CHEMISTRY, 2020, 17 (12) : 959 - 968
[10] Synthesis and Antimicrobial Assessment of Some New 2-(Thiazol-5-yl)-1,3,4-oxadiazoles
Araniciu, Catalin
Oniga, Smaranda Dafina
Stoica, Cristina Ioana
Chifiriuc, Mariana Carmen
Popa, Marcela
Vlase, Laurian
Palage, Mariana
Oniga, Ovidiu
REVISTA DE CHIMIE, 2019, 70 (06): : 1996 - 1999

← 1 2 3 4 5 →