Cross-Coupling of Non-activated Chloroalkanes with Aryl Grignard Reagents in the Presence of Iron/N-Heterocyclic Carbene Catalysts

被引：112

作者：

Ghorai, Sujit K. ^{[1
]}

Jin, Masayoshi ^{[1
,2
]}

Hatakeyama, Takuji ^{[1
]}

Nakamura, Masaharu ^{[1
]}

机构：

[1] Kyoto Univ, Inst Chem Res, Int Res Ctr Elements Sci IRCELS, Kyoto 6110011, Japan

[2] Daiichi Sankyo Co Ltd, Pharmaceut Technol Div, Proc Technol Res Labs, Hiratsuka, Kanagawa 2540014, Japan

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 04期

基金：

日本学术振兴会;

关键词：

UNACTIVATED ALKYL-HALIDES; REACTIVITY; COMPLEXES; CHLORIDES;

D O I：

10.1021/ol2031729

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and high-yielding cross-coupling reaction of various primary, secondary, and tertiary alkyl chlorides with aryl Grignard reagents was achieved by using catalytic amounts of N-heterocyclic carbene ligands and iron salts. This reaction is a simple and efficient arylation method having applicability to a wide range of industrially abundant chloroalkanes, including polychloroalkanes, which are challenging substrates under conventional cross-coupling conditions.

引用

页码：1066 / 1069

页数：4