A total synthesis of spiruchostatin A

被引：56
作者：
Doi, T
Iijima, Y
Kazuo, SY
Ganesan, A
Takahashi, T
机构：
[1] Tokyo Inst Technol, Dept Appl Chem, Meguro Ku, Tokyo 1528552, Japan
[2] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan
[3] Natl Inst Adv Ind Sci & Technol, BIRC, Prot Network Team, Low MW Chem Lab,Kota Ku, Tokyo 1350064, Japan
[4] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 07期
关键词：
spiruchostatin; cyclic depsipeptide; natural product synthesis; asymmetric aldol reaction;
D O I：
10.1016/j.tetlet.2005.12.031
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We achieved the total synthesis of the histone deacetylase inhibitor spiruchostatin A, as the prelude to the preparation of a combinatorial library of its analogues. Two key reactions were an asymmetric acetate aldol reaction using a Zr-enolate and macrolactonization Using the Shiina method. (c) 2005 Published by Elsevier Ltd.
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收藏
页码：1177 / 1180
页数：4
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