Pancreas Transplantation From Donors After Circulatory Death From the United Kingdom

被引：62

作者：

Muthusamy, A. S. R. ^{[1
]}

Mumford, L. ^{[2
]}

Hudson, A. ^{[2
]}

Fuggle, S. V. ^{[1
,2
]}

Friend, P. J. ^{[1
,3
]}

机构：

[1] Churchill Hosp, Oxford Transplant Ctr, Oxford OX3 7LJ, England

[2] NHS Blood & Transplant, Organ Donat & Transplantat Directorate, Bristol, Avon, England

[3] Univ Oxford, Nuffield Dept Surg Sci, Churchill Hosp, Oxford, England

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2012年 / 12卷 / 08期

关键词：

DCD; donation after cardiac death; graft thrombosis; pancreas transplantation; CARDIAC-DEATH; DONATION;

D O I：

10.1111/j.1600-6143.2012.04075.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

This study reports the comparative short-term results of pancreas transplantation from donors after circulatory death (DCD) (Maastricht III & IV), and pancreases from brainstem deceased donors (DBD). Between January 2006 and December 2010, 1009 pancreas transplants were performed in the United Kingdom, with 134 grafts from DCD and 875 from DBD. DCD grafts had no premortem pharmacological interventions performed. One-year pancreas and patient survival was similar between DCD and DBD, with pancreas graft survival significantly better in the DCD cohort if performed as an SPK. Early graft loss due to thrombosis (8% vs. 4%) was mainly responsible for early graft loss in the DCD cohort. These results from donors with broader acceptance criteria in age, body mass index, premortem interventions, etc. suggest that DCD pancreas grafts may have a larger application potential than previously recognized.

引用

页码：2150 / 2156

页数：7

共 10 条

[1] Liver transplantation from controlled non-heartbeating donors: An increased incidence of biliary complications [J].

Abt, P ;

Crawford, M ;

Desai, N ;

Markmann, J ;

Olthoff, K ;

Shaked, A .

TRANSPLANTATION, 2003, 75 (10) :1659-1663

[2] Donation after cardiac death: A 29-year experience [J].

Bellingham, Janet M. ;

Santhanakrishnan, Chandrasekar ;

Neidlinger, Nikole ;

Wai, Philip ;

Kim, Jim ;

Niederhaus, Silke ;

Leverson, Glen E. ;

Fernandez, Luis A. ;

Foley, David P. ;

Mezrich, Joshua D. ;

Odorico, Jon S. ;

Love, Robert B. ;

De Oliveira, Nilto ;

Sollinger, Hans W. ;

D'Alessandro, Anthony M. .

SURGERY, 2011, 150 (04) :692-700

[3]

D'Alessandro Anthony M, 2004, Ann Transplant, V9, P68

[4] Expericne in renal and extrarenal transplantation with donation afeter cardiac death donors with selective use of extracorporeal support [J].

Farney, Alan C. ;

Singh, Rajinder P. ;

Hines, Michael H. ;

Rogers, Jeffrey ;

Hartmann, Erica L. ;

Reeves-Daniel, Amber ;

Gautreaux, Michael D. ;

Iskandar, Samy S. ;

Adams, Patricia L. ;

Stratta, Robert J. .

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2008, 206 (05) :1028-1037

[5] Non-heartbeating donation of kidneys for transplantation [J].

Kootstra, Gauke ;

van Heurn, Ernest .

NATURE CLINICAL PRACTICE NEPHROLOGY, 2007, 3 (03) :154-163

[6] Underutilization of pancreas donors [J].

Krieger, NR ;

Odorico, JS ;

Heisey, DM ;

D'Alessandro, AM ;

Knechtle, SJ ;

Pirsch, JD ;

Sollinger, HW .

TRANSPLANTATION, 2003, 75 (08) :1271-1276

[7]

Lewis Jonathan, 2003, Prog Transplant, V13, P265

[8] A comparison of the results of renal transplantation from non-heart-beating, conventional cadaveric, and living donors [J].

Nicholson, ML ;

Metcalfe, MS ;

White, SA ;

Waller, JR ;

Doughman, TM ;

Horsburgh, T ;

Feehally, J ;

Carr, SJ ;

Veitch, PS .

KIDNEY INTERNATIONAL, 2000, 58 (06) :2585-2591

[9] Outcomes of pancreas transplantation in the United States using cardiac-death donors [J].

Salvalaggio, PR ;

Davies, DB ;

Fernandez, LA ;

Kaufman, DB .

AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (05) :1059-1065

[10] Time to Cardiac Death After Withdrawal of Life-Sustaining Treatment in Potential Organ Donors [J].

Suntharalingam, C. ;

Sharples, L. ;

Dudley, C. ;

Bradley, J. A. ;

Watson, C. J. E. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2009, 9 (09) :2157-2165

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