Chitosan as biomaterial in drug delivery and tissue engineering

被引：514

作者：

Ahsan, Saad M. ^{[1
]}

Thomas, Mathai ^{[2
]}

Reddy, Kranthi K. ^{[3
]}

Sooraparaju, Sujata Gopal ^{[3
]}

Asthana, Amit ^{[1
]}

Bhatnagar, Ira ^{[1
]}

机构：

[1] Ctr Cellular & Mol Biol, Uppal Rd, Hyderabad 500007, Telangana State, India

[2] PSM Coll Dent Sci & Res, Trichur 680519, Kerala, India

[3] MNR Dent Coll & Hosp, Sangareddy 502294, Telangana State, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 110卷

关键词：

Chitosan; Biomedicine; Drug delivery; Gene delivery; Tissue engineering; Denstistry; SELF-ASSEMBLED NANOPARTICLES; HEXA-N-ACETYLCHITOHEXAOSE; WATER-SOLUBLE CHITIN; IN-VIVO EVALUATION; GLYCOL-CHITOSAN; GENE DELIVERY; COMPOSITE SCAFFOLDS; NERVE-REGENERATION; PHOTOCROSSLINKABLE CHITOSAN; PHARMACEUTICAL INTERACTIONS;

D O I：

10.1016/j.ijbiomac.2017.08.140

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chitin is one of the most abundant polysaccharide found on earth. The deacetylated form of chitin viz chitosan has been reported for its various important pharmacological properties and its role in tissue engineering and regenerative medicine is also well documented. Chitosan based bone graft substitutes are biocompatible, biodegradable, osteoconductive, osteoinductive and structurally similar to bone, with excellent mechanical strength and cost effectiveness. Chitosan based hydrogels and wound healing bandages have also found a great market in the field of medicine. More recently, chitosan has gained popularity for its use as a matrix molecule for drug delivery and also finds an upcoming utility in the area of dentistry. The present article has tried to review the latest research on chitosan based tissue engineering constructs, drug delivery vehicles as well as dental care products. An attempt has also been made to discuss the various modifications of chitosan that enhance its use for a given set of applications which would pave a way for future applied research in the field of biomedical innovation and regenerative medicine. (C) 2017 Published by Elsevier B.V.

引用

页码：97 / 109

页数：13

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