TGF-β Inhibitors for Therapeutic Management of Kidney Fibrosis

被引：37

作者：

Park, Cheol Ho ^{[1
]}

Yoo, Tae-Hyun ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Inst Kidney Dis Res, Dept Internal Med, Seoul 03722, South Korea

来源：

PHARMACEUTICALS | 2022年 / 15卷 / 12期

关键词：

TGF-beta; kidney; fibrosis; GROWTH-FACTOR-BETA; BONE MORPHOGENETIC PROTEIN-7; HUMAN OSTEOGENIC PROTEIN-1; TUBULE EPITHELIAL-CELLS; PROMOTES RENAL FIBROSIS; TRANSFORMING GROWTH-FACTOR-BETA-1; DIABETIC-NEPHROPATHY; MESENCHYMAL TRANSITION; DIRECT PHOSPHORYLATION; MOLECULAR-MECHANISMS;

D O I：

10.3390/ph15121485

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Kidney fibrosis is a common pathophysiological mechanism of chronic kidney disease (CKD) progression caused by several underlying kidney diseases. Among various contributors to kidney fibrosis, transforming growth factor-beta 1 (TGF-beta 1) is the major factor driving fibrosis. TGF-beta 1 exerts its profibrotic attributes via the activation of canonical and non-canonical signaling pathways, which induce proliferation and activation of myofibroblasts and subsequent accumulation of extracellular matrix. Over the past few decades, studies have determined the TGF-beta 1 signaling pathway inhibitors and evaluated whether they could ameliorate the progression of CKD by hindering kidney fibrosis. However, therapeutic strategies that block TGF-beta 1 signaling have usually demonstrated unsatisfactory results. Herein, we discuss the therapeutic concepts of the TGF-beta 1 signaling pathway and its inhibitors and review the current state of the art regarding regarding TGF-beta 1 inhibitors in CKD management.

引用

页数：17

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