Midkine as a regulator of B cell survival in health and disease

被引:15
作者
Cohen, Sivan [1 ]
Shachar, Idit [1 ]
机构
[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel
关键词
BCR; BAFF; MIF; CD74; invariant chain; B cells; survival; CHRONIC LYMPHOCYTIC-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; TUMOR-NECROSIS-FACTOR; BRUTONS TYROSINE KINASE; BINDING GROWTH-FACTOR; REED-STERNBERG CELLS; INVARIANT CHAIN; HODGKINS-DISEASE; SIGNAL-TRANSDUCTION; NEGATIVE SELECTION;
D O I
10.1111/bph.12419
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In healthy individuals, the pool of peripheral lymphocytes is constant in size. The control of lymphoid homeostasis is the result of a very fine balance between lymphocyte production, survival and proliferation. Survival factors have been shown to play a critical role in maintaining the correct size of lymphocyte populations. Midkine, a heparin-binding cytokine was recently shown to be involved in cell proliferation, differentiation and apoptosis in various cell types including normal and malignant B cells. This review focuses on the role of midkine in the regulation of peripheral B cell survival in health and disease. Linked ArticlesThis article is part of a themed section on Midkine. To view the other articles in this section visit
引用
收藏
页码:888 / 895
页数:8
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