Novel 5-amino-6-methylquinolone antibacterials: A new class of non-6-fluoroquinolones

被引：14
作者：
Hong, CY
Kim, SH
Kim, YK
机构：
[1] Biotech Research Institute, LG Chem Research Park, PO BOX 61, Yu-Sung, Tae-Jon
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 14期
关键词：
D O I：
10.1016/S0960-894X(97)00324-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel 5-amino-6-methylquinoline carboxylic acid was synthesized from 2,3,4-trifluoro aniline in 12 steps and coupled with various types of amines to furnish new quinolone antibacterial agents. Depending on the structure of amine, some of quinolones showed comparable activity to ciprofloxacin or better Gram positive activity than ciprofloxacin, demonstrating that the C6 fluorine atom is not a necessary requirement for good antibacterial potency. (C) 1997 Elsevier Science Ltd.
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页码：1875 / 1878
页数：4
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