Human chorionic gonadotropin-secreting clear cell renal cell carcinoma with paraneoplastic gynaecomastia

被引：12

作者：

Ilyas, Mohammed Iyoob Mohammed ^{[1
]}

Turner, Gareth D. H. ^{[2
]}

Cranston, David ^{[1
]}

机构：

[1] Churchill Hosp, Dept Urol, Oxford Radcliffe Hosp Trust, Oxford OX3 7LJ, England

[2] John Radcliffe Hosp, Dept Cellular Pathol, Oxford OX3 9DU, England

来源：

SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY | 2008年 / 42卷 / 06期

关键词：

Ectopic hormones; erythropoietin; gynaecomastia; human chorionic gonadotropin; paraneoplastic endocrine syndrome; renal cell carcinoma;

D O I：

10.1080/00365590802468834

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A 60-year-man presented with painful gynaecomastia and polycythaemia due to a -human chorionic gonadotropin (HCG)-secreting clear cell renal cell carcinoma. A computed tomographic scan of his chest, abdomen and pelvis showed an enhancing 99cm mass in the right kidney suggestive of a renal cell carcinoma. He underwent right radical nephrectomy and the histology showed a clear cell renal cell carcinoma. Following his nephrectomy, over the next 6 months, his gynaecomastia regressed and serum -HCG levels became undetectable. Nine months after his nephrectomy, he developed a paratesticular lesion involving scrotal skin, for which he underwent a right radical orchidectomy. Histopathology of the paratesticular lesion showed metastatic renal cell carcinoma.

引用

页码：555 / 557

页数：3

共 8 条

[1]

Gold P J, 1996, Semin Urol Oncol, V14, P216

[2] The free β-subunit of human chorionic gonadotropin as a prognostic factor in renal cell carcinoma [J].

Hotakainen, K ;

Ljungberg, B ;

Paju, A ;

Rasmuson, T ;

Alfthan, H ;

Stenman, UH .

BRITISH JOURNAL OF CANCER, 2002, 86 (02) :185-189

[3] Ectopic hCGβ expression by epithelial cancer:: Malignant behaviour, metastasis and inhibition of tumor cell apoptosis [J].

Iles, R. K. .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2007, 260 :264-270

[4]

NGONGA FG, 2005, ANN ITAL MED INT, V20, P28

[5]

SHAH VM, 1987, BRIT J EXP PATHOL, V68, P871

[6] Sarcomatoid renal cell carcinoma with a chromophobe component producing beta-human chorionic gonadotropin [J].

Shimomura, T ;

Ikemoto, I ;

Yamada, H ;

Hayashi, N ;

Ito, H ;

Oishi, Y .

INTERNATIONAL JOURNAL OF UROLOGY, 2005, 12 (09) :835-837

[7] PROLACTIN SECRETING RENAL-CELL CARCINOMA [J].

STANISIC, TH ;

DONOVAN, J .

JOURNAL OF UROLOGY, 1986, 136 (01) :85-86

[8]

Yaturu Subhashini, 2003, Endocr Pract, V9, P233

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