Influence of Off-resonance in myocardial T1-mapping using SSFP based MOLLI method

被引：72
作者：
Kellman, Peter [1 ]
Herzka, Daniel A. [2 ]
Arai, Andrew E. [1 ]
Hansen, Michael Schacht [1 ]
机构：
[1] NHLBI, NIH, DHHS, Bethesda, MD 20892 USA
[2] Johns Hopkins Univ, Sch Med, Baltimore, MD USA
来源：
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE | 2013年 / 15卷
基金：
美国国家卫生研究院;
关键词：
T1; map; Error; Off-resonance; MOLLI; Shim; SSFP; CARDIOVASCULAR MAGNETIC-RESONANCE; INVERSION-RECOVERY MOLLI; T1; VALIDATION;
D O I：
10.1186/1532-429X-15-63
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Myocardial T1-mapping methods such as MOLLI use SSFP readout and are prone to frequency-dependent error in T1-measurement. A significant error in T1 may result at relatively small off-resonance frequencies that are well within the region without banding artifacts. Methods: The sensitivity of T1-estimates based on the SSFP based MOLLI sequence to errors in center frequency are calculated by means of a Bloch simulation and validated by phantom measurements. Typical off-resonance errors following local cardiac shimming are determined by field mapping at both 1.5 and 3.0T. In vivo examples demonstrate the artifactual appearance of T1-maps in the presence of off-resonance variation. Results: Off-resonance varied 61.8 +/- 15.5 Hz (mean +/- SD, n = 18) across the heart at 1.5T and 125.0 +/- 40.6 Hz (mean +/- SD, n = 18) at 3.0T. For T1 = 1000 ms, the variation in T1 due to off-resonance variation was approximately 20 ms at 62 Hz, and > 50 ms at 125 Hz. Conclusions: Regional variations due to the inability to completely shim the B0-field variation around the heart appear as regional variation in T1, which is artifactual.
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页数：8
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