Strong correlation between diet and development of colorectal cancer

被引:29
作者
Cappellani, Alessandro [1 ]
Zanghi, Antonio [1 ]
Di Vita, Maria [1 ]
Cavallaro, Andrea [1 ]
Piccolo, Gaetano [1 ]
Veroux, Pierfrancesco [2 ]
Lo Menzo, Emanuele [3 ]
Cavallaro, Vincenzo [4 ]
de Paoli, Paolo [5 ]
Veroux, Massimiliano [2 ]
Berretta, Massimiliano [6 ]
机构
[1] Univ Catania, Azienda Osped Univ, Policlin Vittorio Emanuele, Dept Surg,Gen Surg & Breast Unit, I-95123 Catania, Italy
[2] Univ Catania, Dept Surg Transplantat & Adv Technol, I-95123 Catania, Italy
[3] Univ Maryland, Div Laparoscop & Bariatr Surg, Baltimore, MD 21201 USA
[4] Univ Policlin, Azienda Osped, Univ Catania, Dept Surg,Digest Surg Unit, I-95123 Catania, Italy
[5] IRCCS, Natl Canc Inst, Sci Direct, I-33081 Aviano, PN, Italy
[6] IRCCS, Natl Canc Inst, Dept Med Oncol, I-33081 Aviano, PN, Italy
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2013年 / 18卷
关键词
Colorectal cancer; Dietary habits; Fibers Intake; Folate; Meat Intake; Methylation; Obesity; Review; META-ANALYTICAL APPROACH; UNITED-STATES WOMEN; C-REACTIVE PROTEIN; COLON-CANCER; RISK-FACTORS; CIGARETTE-SMOKING; MEAT CONSUMPTION; PHYSICAL-ACTIVITY; DNA METHYLATION; ADIPOSE-TISSUE;
D O I
10.2741/4095
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Multiple factors have been described among the causes of non-hereditary colorectal cancer. In Western countries, the most common risk factors include upper-middle socioeconomic status and dietary regimens rich in proteins and animal fats. High consumption of red meats, smoked foods, cold cuts, or canned foods is believed to contribute to carcinogenesis as they directly affect epithlial turnover and cause metabolism of biliary acids. Dietary fibers have protective effects in that they capture the fats and biliary acids, thereby inhibiting their activity. Tobacco smoking acts both locally and systemically on the colorectal mucosa through the production of carcinogenic agents. Finally, the action of alcohol, in association with nicotine addiction, also increases the risk of developing colorectal tumors. Knowledge of dietary and environmental factors is of paramount importance in implementing preventive strategies for colorectal cancer.
引用
收藏
页码:190 / 198
页数:9
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