Mismatch repair in replication fidelity, genetic recombination, and cancer biology

被引：1310
作者：
Modrich, P
Lahue, R
机构：
[1] DUKE UNIV, MED CTR, DEPT BIOCHEM, DURHAM, NC 27710 USA
[2] UNIV MASSACHUSETTS, MED CTR, DEPT BIOCHEM & MOLEC BIOL, WORCESTER, MA 01655 USA
来源：
ANNUAL REVIEW OF BIOCHEMISTRY | 1996年 / 65卷
关键词：
mutation; mutator; DNA repair; DNA replication; genetic recombination;
D O I：
10.1146/annurev.bi.65.070196.000533
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mismatch repair stabilizes the cellular genome by correcting DNA replication errors and by blocking recombination events between divergent DNA sequences. The reaction responsible for strand-specific correction of mispaired bases has been highly conserved during evolution, and homologs of bacterial MutS and MutL, which play key roles in mismatch recognition and initiation of repair, have been identified in yeast and mammalian cells. Inactivation of genes encoding these activities results in a large increase in spontaneous mutability, and in the case of mice and men, predisposition to tumor development.
引用
收藏
页码：101 / 133
页数：33
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