Response to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder: the Spanish multicenter DIHANA study

被引：7

作者：

Valdizan-Uson, J. R. ^{[1
]}

Canovas-Martinez, A. ^{[2
]}

De Lucas-Taracena, M. T. ^{[3
]}

Diaz-Atienza, F. ^{[4
]}

Eddy-Ives, L. S. ^{[5
]}

Fernandez-Jaen, A. ^{[6
]}

Fernandez-Perez, M. ^{[7
]}

Garcia-Giral, M. ^{[8
]}

Garcia-Magan, P. ^{[9
]}

Garraus-Oneca, M. ^{[10
]}

Idiazabal-Alecha, M. A. ^{[11
]}

Lopez-Benito, M. ^{[12
]}

Lorenzo-Sanz, G. ^{[13
]}

Martinez-Anton, J. ^{[14
]}

Martinez-Granero, M. A. ^{[15
]}

Montanes-Rada, F. ^{[15
]}

Mulas-Delgado, F. ^{[16
]}

Ochando-Perales, G. ^{[16
]}

Ortega-Garcia, E. ^{[17
]}

Pelaz-Antolin, A. ^{[18
]}

Ramos-Quiroga, J. A. ^{[19
]}

Ruiz-Sanz, F. C. ^{[20
]}

Vaquerizo-Madrid, J. ^{[21
]}

Yusta-Izquierdo, A. ^{[22
]}

机构：

[1] Clin Montpellier, Unidad Trastornos Neurofunc, Zaragoza 50012, Spain

[2] Hosp Dr Peset, Valencia, Spain

[3] Hosp 12 Octubre, E-28041 Madrid, Spain

[4] Hosp Virgen Nieves, Granada, Spain

[5] Ctr Medic St Ramon, Barcelona, Spain

[6] Hosp Univ Quiron, Madrid, Spain

[7] Ctr Salud La Felguera, Sama De Langreo, Asturias, Spain

[8] Hosp Clin Barcelona, Barcelona, Spain

[9] Unidad Salud Mental, Talavera De La Reina, Spain

[10] Univ Navarra Clin, Pamplona, Spain

[11] Hosp Ntra Sra Pilar, Barcelona, Spain

[12] Ctr Salud Contrueces, Gijon, Spain

[13] Hosp Ramon & Cajal, E-28034 Madrid, Spain

[14] Complejo Hosp Carlos Haya, Malaga, Spain

[15] Hosp Univ Fdn Alcorcon, Madrid, Spain

[16] Hosp Univ La Fe, Valencia, Spain

[17] Complejo Asistencial Univ Leon, Leon, Spain

[18] Ctr Salud Mental, Alcala De Henares, Spain

[19] Univ Autonoma Barcelona, CIBERSAM, Hosp Univ Vall Hebron, Dept Psychiat & Legal Med, Barcelona, Spain

[20] Hosp Gen Rio Carrion, Palencia, Spain

[21] Hosp Materno Infantil, Badajoz, Spain

[22] Hosp Univ, Guadalajara, Spain

来源：

NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2013年 / 9卷

关键词：

attention deficit hyperactivity disorder; ADHD; pharmacologic treatment; methylphenidate; satisfaction; DEFICIT HYPERACTIVITY DISORDER; IMMEDIATE-RELEASE METHYLPHENIDATE; INTERNATIONAL CONSENSUS STATEMENT; AGE-DEPENDENT DECLINE; FOLLOW-UP; STIMULANT MEDICATIONS; PRESCHOOL-CHILDREN; PSYCHIATRIC STATUS; ADHD; SAFETY;

D O I：

10.2147/NDT.S35836

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The purpose of this multicenter Spanish study was to evaluate the response to immediate-release methylphenidate by children and adults diagnosed with attention-deficit/hyperactivity disorder (ADHD), as well as to obtain information on current therapy patterns and safety characteristics. Methods: This multicenter, observational, retrospective, noninterventional study included 730 patients aged 4-65 years with a diagnosis of ADHD. Information was obtained based on a review of medical records for the years 2002-2006 in sequential order. Results: The ADHD predominantly inattentive subtype affected 29.7% of patients, ADHD predominantly hyperactive-impulsive was found in 5.2%, and the combined subtype in 65.1%. Overall, a significant lower Clinical Global Impression (CGI) score and mean number of DSM-IV TR (Diagnostic and Statistical Manual of Mental Disorders Fourth Edition, Text Revision) symptoms by subtype were found after one year of treatment with immediate-release methylphenidate; CGI decreased from 4.51 to 1.69, symptoms of inattention from 7.90 to 4.34, symptoms of hyperactivity from 6.73 to 3.39, and combined subtype symptoms from 14.62 to 7.7. Satisfaction with immediate-release methylphenidate after one year was evaluated as "very satisfied" or "satisfied" by 86.90% of the sample; 25.75% of all patients reported at least one adverse effect. At the end of the study, 41.47% of all the patients treated with immediate-release methylphenidate were still receiving it, with a mean time of 3.80 years on therapy. Conclusion: Good efficacy and safety results were found for immediate-release methylphenidate in patients with ADHD.

引用

页码：211 / 218

页数：8

共 47 条

[1]

[Anonymous], 1991, INT GUID ETH REV EP

[2]

[Anonymous], CAN J CLIN PHARM

[3]

[Anonymous], CLIN GUIDE ADULT ADH

[4]

[Anonymous], 2000, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425787

[5] Is adult attention deficit hyperactivity disorder a valid diagnosis in the presence of high IQ? [J].

Antshel, K. M. ;

Faraone, S. V. ;

Maglione, K. ;

Doyle, A. ;

Fried, R. ;

Seidman, L. ;

Biederman, J. .

PSYCHOLOGICAL MEDICINE, 2009, 39 (08) :1325-1335

[6] Young adult follow-up of hyperactive children: antisocial activities and drug use [J].

Barkley, RA ;

Fischer, M ;

Smallish, L ;

Fletcher, K .

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 2004, 45 (02) :195-211

[7]

Barkley RA, 2002, CLIN CHILD FAM PSYCH, V5, P89

[8] Functional impairments in adults with self-reports of diagnosed ADHD: A controlled study of 1001 adults in the community [J].

Biederman, J ;

Faraone, SV ;

Spencer, TJ ;

Mick, E ;

Monuteaux, MC ;

Aleardi, M .

JOURNAL OF CLINICAL PSYCHIATRY, 2006, 67 (04) :524-540

[9] Age-dependent decline of symptoms of attention deficit hyperactivity disorder: Impact of remission definition and symptom type [J].

Biederman, J ;

Mick, E ;

Faraone, SV .

AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (05) :816-818

[10] Genetic Epidemiology of Attention Deficit Hyperactivity Disorder (ADHD Index) in Adults [J].

Boomsma, Dorret I. ;

Saviouk, Viatcheslav ;

Hottenga, Jouke-Jan ;

Distel, Marijn A. ;

de Moor, Marleen H. M. ;

Vink, Jacqueline M. ;

Geels, Lot M. ;

van Beek, Jenny H. D. A. ;

Bartels, Meike ;

de Geus, Eco J. C. ;

Willemsen, Gonneke .

PLOS ONE, 2010, 5 (05)

← 1 2 3 4 5 →