Association of pre-miR-146a rs2910164 Polymorphism with the Risk of Head and Neck Cancer

被引：0
作者：
Orsos, Zsuzsa [1 ]
Szanyi, Istvan [2 ]
Csejtei, Andras [3 ]
Gerlinger, Imre [2 ]
Ember, Istvan [1 ]
Kiss, Istvan [1 ]
机构：
[1] Univ Pecs, Fac Med, Dept Publ Hlth, Pecs, Hungary
[2] Univ Pecs, Fac Med, Dept Otorhinolaryngol & Head & Neck Surg, Pecs, Hungary
[3] Markusovszky Cty Hosp, Dept Oncoradiol, Szombathely, Hungary
来源：
ANTICANCER RESEARCH | 2013年 / 33卷 / 01期
关键词：
miR-146a; polymorphism; squamous cell carcinoma; head and neck; NF-KAPPA-B; HEPATOCELLULAR-CARCINOMA; FUNCTIONAL POLYMORPHISM; CERVICAL-CANCER; MICRORNA GENES; GASTRIC-CANCER; PRE-MICRORNAS; EXPRESSION; MIR-146A; SUSCEPTIBILITY;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Over- or underexpression of miR-146a has been reported in several different human tumor types, and a polymorphism in its precursor form (pre-miR-146a rs2910164 G/C) has been recently studied in connection with cancer susceptibility. The aim of the present study was to investigate the possible influence of the pre-miR-146a rs2910164 polymorphism on the risk of squamous cell carcinoma of the head and neck (HNSCC). Patients and Methods: The study included 468 patients with HNSCC and 468 cancer-free, age-, gender-, and smoking-matched controls. The miR-146a genotypes were determined using polymerase chain reaction with confronting two-pair primers, and their distribution was compared by multivariate binary logistic regression analysis. Results: Occurrence of heterozygous (odds ratio, OR=1.46, 95% confidence interval, CI=1.10-1.95, p=0.009) and C/C homozygous (OR=2.37, 95% CI=1.01-5.60, p=0.048) individuals was significantly more frequent among patients with HNSCC than in the control group. Conclusion: The pre-miR/146a C allele may contribute to an increased susceptibility to HNSCC.
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页码：341 / 346
页数：6
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