Polyphenols as Modulators of Aquaporin Family in Health and Disease

被引:30
作者
Fiorentini, Diana [1 ]
Zambonin, Laura [1 ]
Sega, Francesco Vieceli Dalla [1 ]
Hrelia, Silvana [2 ]
机构
[1] Univ Bologna, Dept Pharm & Biotechnol, Alma Mater Studiorum, I-40126 Bologna, Italy
[2] Univ Bologna, Dept Life Qual Studies, Alma Mater Studiorum, I-47921 Rimini, Italy
关键词
SPINAL-CORD-INJURY; HYDROGEN-PEROXIDE; WATER CHANNELS; EPIGALLOCATECHIN GALLATE; APPLE POLYPHENOL; OXIDATIVE STRESS; GENE-EXPRESSION; DOWN-REGULATION; CEREBRAL EDEMA; BRAIN;
D O I
10.1155/2015/196914
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Polyphenols are bioactive molecules widely distributed in fruits, vegetables, cereals, and beverages. Polyphenols in food sources are extensively studied for their role in the maintenance of human health and in the protection against development of chronic/degenerative diseases. Polyphenols act mainly as antioxidant molecules, protecting cell constituents against oxidative damage. The enormous number of polyphenolic compounds leads to huge different mechanisms of action not fully understood. Recently, some evidence is emerging about the role of polyphenols, such as curcumin, pinocembrin, resveratrol, and quercetin, in modulating the activity of some aquaporin (AQP) isoforms. AQPs are integral, small hydrophobic water channel proteins, extensively expressed in many organs and tissues, whose major function is to facilitate the transport of water or glycerol over cell plasma membranes. Here we summarize AQP physiological functions and report emerging evidence on the implication of these proteins in a number of pathophysiological processes. In particular, this review offers an overview about the role of AQPs in brain, eye, skin diseases, and metabolic syndrome, focusing on the ability of polyphenols to modulate AQP expression. This original analysis can contribute to elucidating some peculiar effects exerted by polyphenols and can lead to the development of an innovative potential preventive/therapeutic strategy.
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页数:8
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