Catalytic MBH reaction of β-substituted nitroalkenes with azodicarboxylates

被引：29
作者：
Chen, Xiang-Yu [1 ]
Xia, Fei [1 ]
Ye, Song [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 34期
基金：
中国国家自然科学基金;
关键词：
BAYLIS-HILLMAN REACTION; ASYMMETRIC MICHAEL ADDITION; TO-TAIL DIMERIZATION; CONJUGATED NITROALKENES; HIGHLY EFFICIENT; NUCLEOPHILIC CARBENES; ANTICANCER ACTIVITY; 4+2 CYCLOADDITION; MECHANISM; ALDEHYDES;
D O I：
10.1039/c3ob40804c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unprecedented N-heterocyclic carbene (NHC) catalyzed Morita-Baylis-Hillman (MBH) reaction of beta-substituted nitroalkenes and azodicarboxylates has been developed. Both beta-aryl and beta-alkyl nitroalkenes worked well for the reaction using 5 mol% of NHC catalyst, giving the desired alpha-hydrazino-alpha,beta-unsaturated nitroalkenes in good to excellent yields.
引用
收藏
页码：5722 / 5726
页数：5
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