Catalytic MBH reaction of β-substituted nitroalkenes with azodicarboxylates

被引：29

作者：

Chen, Xiang-Yu ^{[1
]}

Xia, Fei ^{[1
]}

Ye, Song ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 34期

基金：

中国国家自然科学基金;

关键词：

BAYLIS-HILLMAN REACTION; ASYMMETRIC MICHAEL ADDITION; TO-TAIL DIMERIZATION; CONJUGATED NITROALKENES; HIGHLY EFFICIENT; NUCLEOPHILIC CARBENES; ANTICANCER ACTIVITY; 4+2 CYCLOADDITION; MECHANISM; ALDEHYDES;

D O I：

10.1039/c3ob40804c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented N-heterocyclic carbene (NHC) catalyzed Morita-Baylis-Hillman (MBH) reaction of beta-substituted nitroalkenes and azodicarboxylates has been developed. Both beta-aryl and beta-alkyl nitroalkenes worked well for the reaction using 5 mol% of NHC catalyst, giving the desired alpha-hydrazino-alpha,beta-unsaturated nitroalkenes in good to excellent yields.

引用

页码：5722 / 5726

页数：5

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