Important prognostic factors for the long-term survival of lung cancer subjects in Taiwan

被引：22

作者：

Chiang, Tai-An ^{[1
]}

Chen, Ping-Ho

Wu, Pei-Fen ^{[2
]}

Wang, Tsu-Nai ^{[3
]}

Chang, Po-Ya ^{[4
]}

Ko, Albert Min-Shan ^{[5
]}

Huang, Ming-Shyan ^{[7
]}

Ko, Ying-Chin ^{[5
,6
]}

机构：

[1] Chung Hwa Univ Med Technol, Coll Med & Life Sci, Dept Med Technol, Tainan, Taiwan

[2] Tajen Univ, Dept Occupat Safety & Hyg, Pingtung, Taiwan

[3] Kaohsiung Med Univ, Fac Publ Hlth, Kaohsiung, Taiwan

[4] Tajen Univ, Dept Healthcare Adm, Pingtung, Taiwan

[5] Kaohsiung Med Univ, Ctr Excellence Environm Med, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ, Coll Med, Fac Med, Dept Publ Hlth, Kaohsiung, Taiwan

[7] Kaohsiung Med Univ, Dept Internal Med, Div Chest Med, Kaohsiung, Taiwan

来源：

BMC CANCER | 2008年 / 8卷 / 1期

关键词：

D O I：

10.1186/1471-2407-8-324

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: This study used a large-scale cancer database in determination of prognostic factors for the survival of lung cancer subjects in Taiwan. Methods: Total of 24,910 subjects diagnosed with lung cancer was analysed. Survival estimates by Kaplan-Meier methods. Cox proportional-hazards model estimated the death risk (hazard ratio (HR)) for various prognostic factors. Results: The prognostic indicators associated with a higher risk of lung cancer deaths are male gender (males versus females; HR = 1.07, 95% confidence intervals (CI): 1.03-1.11), males diagnosed in later periods (shown in 1991-1994 versus 1987-1990; HR = 1.13), older age at diagnosis, large cell carcinoma (LCC)/small cell carcinoma (SCC), and supportive care therapy over chemotherapy. The overall 5-year survival rate for lung cancer death was significantly poorer for males (21.3%) than females (23.6%). Subjects with squamous cell carcinoma (SQCC) and treatment by surgical resection alone had better prognosis. We find surgical resections to markedly increase 5-year survival rate from LCC, decreased risk of death from LCC, and no improved survival from SCC. Conclusion: Gender and clinical characteristics (i.e. diagnostic period, diagnostic age,

引用

页数：8

共 29 条

[1] The female gender has a positive effect on survival independent of background life expectancy following surgical resection of primary non-small cell lung cancer:: a study of absolute and relative survival over 15 years [J].

Båtevik, R ;

Grong, K ;

Segadal, L ;

Stangeland, L .

LUNG CANCER, 2005, 47 (02) :173-181

[2] Lung cancer: district active treatment rates affect survival [J].

Cartman, ML ;

Hatfield, AC ;

Muers, MF ;

Peake, MD ;

Haward, RA ;

Forman, D .

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 2002, 56 (06) :424-429

[3] SEX-DIFFERENCES IN MEDICAL-CARE UTILIZATION - AN EMPIRICAL-INVESTIGATION [J].

CLEARY, PD ;

MECHANIC, D ;

GREENLEY, JR .

JOURNAL OF HEALTH AND SOCIAL BEHAVIOR, 1982, 23 (02) :106-119

[4]

DENISE O, 1998, ANN THORAC SURG, V66, P1140

[5]

*DEP HLTH EX YUAN, 1997, EST DAT BANK DOM MED

[6]

*DEP HLTH EX YUAN, 2003, CANC REG ANN REP

[7]

FERLAY J, 2003, GLOBOCAN 2002 CANC I

[8]

Gavin A T, 2003, Ir Med J, V96, P237

[9] BRONCHOGENIC CANCER IN PATIENTS UNDER 40 YEARS OLD - THE EXPERIENCE OF A LATIN-AMERICAN COUNTRY [J].

GREEN, LS ;

FORTOUL, TI ;

PONCIANO, G ;

ROBLES, C ;

RIVERO, O .

CHEST, 1993, 104 (05) :1477-1481

[10]

Groeger AM, 1997, ANTICANCER RES, V17, P2843

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