Lipase-catalyzed kinetic resolution of trans-2,5-disubstituted pyrrolidine derivatives

被引：8
|
作者：
Kawanami, Y
Moriya, H
Goto, Y
Tsukao, K
Hashimoto, M
机构：
[1] Department of Chemistry, Faculty of Education, Kagawa University, Takamatsu
来源：
TETRAHEDRON | 1996年 / 52卷 / 02期
关键词：
D O I：
10.1016/0040-4020(95)00907-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Enantioselective preparation of C-2-symmetric (-)-(2S,5S)-N-benzyl-trans-2,5-bis(acetoxymethyl)pyrrolidine was carried out by the lipase-catalyzed hydrolysis of racemic diacetate. Organic co-solvent affected the enantioselectivity and 50% DMSO in the phosphate buffer was found to be the optimal solvent system. A possible active site model was also described.
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页码：565 / 570
页数：6
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