CAR T cell immunotherapy for human cancer

被引：2277

作者：

June, Carl H. ^{[1
,2
,3
]}

O'Connor, Roddy S. ^{[1
,2
]}

Kawalekar, Omkar U. ^{[1
]}

Ghassemi, Saba ^{[1
,2
]}

Milone, Michael C. ^{[1
,3
]}

机构：

[1] Perlman Sch Med, Ctr Cellular Immunotherapies, Philadelphia, PA 19104 USA

[2] Univ Penn, Parker Inst Canc Immunotherapy, Philadelphia, PA 19104 USA

[3] Perlman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

SCIENCE | 2018年 / 359卷 / 6382期

关键词：

CHIMERIC-ANTIGEN-RECEPTOR; CD19; REGRESSION; RECOGNITION; REMISSIONS; EXPRESSION; TOXICITY; THERAPY; PERSISTENCE; SENSITIVITY;

D O I：

10.1126/science.aar6711

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly advanced from a promising form of immuno-oncology in preclinical models to the recent commercial approvals of chimeric antigen receptor (CAR) T cells to treat leukemia and lymphoma. This Review describes opportunities and challenges for entering mainstream oncology that presently face the CAR T field, with a focus on the challenges that have emerged over the past several years.

引用

页码：1361 / 1365

页数：5

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