Amination of 2-chloro- and 2,4-dichloropyrimidines by polyamines

A study was carried out on the amination of 2-chloro-and 2,4-dichloropyrimidines by linear polyamines and oxadiamines under catalytic and noncatalytic conditions. The reaction of excess polyamine with 2-chloropyrimidine gives the corresponding 2-aminopyrimidines, while the reaction of polyamines with excess of 2-chloropyrimidine gives di-, tri-, and tetraarylated derivatives. The reaction of 2,4-dichloropyrimidine with diamines was studied with different ratios of the starting reagents. The ratios of the products of substitution at pyrimidine C-2 and C-4 were found.