Asymmetric Catalysis for the Synthesis of Spirocyclic Compounds

被引：260
作者：
Franz, Annaliese K. [1 ]
Hanhan, Nadine V. [1 ]
Ball-Jones, Nicolas R. [1 ]
机构：
[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA
来源：
ACS CATALYSIS | 2013年 / 3卷 / 04期
关键词：
spirooxindole; asymmetric; catalytic; spirocyclic; spirocenter; spiroketals; spirolactones; HIGHLY ENANTIOSELECTIVE SYNTHESIS; ORGANOCATALYTIC DOMINO REACTIONS; INTRAMOLECULAR HECK REACTIONS; QUATERNARY CARBON CENTERS; 3+2 ANNULATION; DIELS-ALDER; 1,3-DIPOLAR CYCLOADDITION; SEMIPINACOL REARRANGEMENT; STEREOSELECTIVE-SYNTHESIS; PALLADIUM(II) COMPLEXES;
D O I：
10.1021/cs300801y
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Spirocycles provide an exciting platform to develop and understand the reactivity and selectivity for a wide variety of catalysts while affording diverse strategies to access molecules with important applications. This review features recent examples in which a spirocenter is formed within the key step of a catalytic asymmetric process, in either an intramolecular or intermolecular fashion. Examples highlight notable spirocyclization strategies and compare the reactivity and selectivity for different classes of chiral organocatalysts and organometallic catalysts.
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页码：540 / 553
页数：14
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