Asymmetric Catalysis for the Synthesis of Spirocyclic Compounds

被引：264

作者：

Franz, Annaliese K. ^{[1
]}

Hanhan, Nadine V. ^{[1
]}

Ball-Jones, Nicolas R. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

ACS CATALYSIS | 2013年 / 3卷 / 04期

关键词：

spirooxindole; asymmetric; catalytic; spirocyclic; spirocenter; spiroketals; spirolactones; HIGHLY ENANTIOSELECTIVE SYNTHESIS; ORGANOCATALYTIC DOMINO REACTIONS; INTRAMOLECULAR HECK REACTIONS; QUATERNARY CARBON CENTERS; 3+2 ANNULATION; DIELS-ALDER; 1,3-DIPOLAR CYCLOADDITION; SEMIPINACOL REARRANGEMENT; STEREOSELECTIVE-SYNTHESIS; PALLADIUM(II) COMPLEXES;

D O I：

10.1021/cs300801y

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Spirocycles provide an exciting platform to develop and understand the reactivity and selectivity for a wide variety of catalysts while affording diverse strategies to access molecules with important applications. This review features recent examples in which a spirocenter is formed within the key step of a catalytic asymmetric process, in either an intramolecular or intermolecular fashion. Examples highlight notable spirocyclization strategies and compare the reactivity and selectivity for different classes of chiral organocatalysts and organometallic catalysts.

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页码：540 / 553

页数：14

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