Sorafenib and entecavir: The dioscuri of treatment for advanced hepatocellular carcinoma?

被引：4
作者：
D'Angelo, Salvatore [1 ]
Secondulfo, Mario [1 ]
De Cristofano, Raffaele [1 ]
Sorrentino, Paolo [1 ]
机构：
[1] SG Moscati Hosp, Liver Unit, I-83100 Avellino, Italy
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2013年 / 19卷 / 14期
关键词：
Entecavir; Hepatocellular carcinoma; Hepatitis B virus; Liver function; Sorafenib; HEPATITIS-B-VIRUS; CIRRHOSIS; EFFICACY; INFECTION; THERAPY; CANCER;
D O I：
10.3748/wjg.v19.i14.2141
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatitis B virus (HBV) is responsible for 50%-80% of cases of hepatocellular carcinoma (HCC) worldwide. Entecavir (ET) is a potent inhibitor of chronic HBV-DNA polymerase, inhibiting both the priming and elongation steps of viral DNA replication. Sorafenib (SO) has proven efficacy in prolonging survival in patients with advanced HCC. In this frontier report we discuss a possible way to optimize treatment outcomes in patients with HBV and HCC by treatment with ET and SO, on the basis of our practice and published evidence from the literature. (C) 2013 Baishideng. All rights reserved.
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页码：2141 / 2143
页数：3
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