The effect of oophorectomy on epidural fibrosis after laminectomy: an experimental study in rats

被引：5

作者：

Circi, Esra ^{[1
]}

Ozalay, Metin ^{[2
]}

Caylak, Berrin ^{[3
]}

Bacanli, Didem ^{[4
]}

Derincek, Alihan ^{[2
]}

Tuncay, I. Cengiz ^{[2
]}

机构：

[1] Istanbul Training & Res Hosp, Dept Orthoped & Traumatol, Istanbul, Turkey

[2] Baskent Univ, Fac Med, Dept Orthoped & Traumatol, TR-06490 Ankara, Turkey

[3] Baskent Univ, Fac Med, Dept Pathol, TR-06490 Ankara, Turkey

[4] Baskent Univ, Fac Med, Expt Res Ctr, TR-06490 Ankara, Turkey

来源：

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA | 2013年 / 47卷 / 03期

关键词：

Epidural fibrosis; histological comparison; laminectomy; estrogen; rat; ANTERIOR CRUCIATE LIGAMENT; SCAR FORMATION; PERIDURAL SCAR; LUMBAR SPINE; PREVENTION; ESTROGEN; DISKECTOMY; SURGERY; PAIN;

D O I：

10.3944/AOTT.2013.2792

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: The aim of this study was to examine the effect of oophorectomy in the formation of epidural fibrosis in a rat laminectomy model. Methods: Thirty-six 12-month-old adult female Sprague-Dawley rats were used in this study. Rats were evenly divided into two groups; oophorectomized and sham-operated. Bilateral oophorectomy was performed on the 18 rats in the oophorectomized group. Three weeks after oophorectomy, rats in both groups underwent complete bilateral laminectomy at the L2 and L3 vertebral levels. Rats were divided into 3 equal groups and sacrificed in groups of 4 at the 4th, 8t, and 12th weeks postoperatively and the lumbar spine excised en bloc, fixed and decalcified. Sections were stained with hematoxylin and eosin and Masson's trichrome were used to evaluate epidural fibrosis, acute inflammation, chronic inflammation, and vascular proliferation. Results: The mean histological sum grade of the epidural fibrosis was greater in the oophorectomized group (p>0.05). Conclusion: Endogenous estrogen could have an effect on epidural fibrosis formation after lumbar laminectomy in rats.

引用

页码：193 / 200

页数：8

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