Click Chemistry for Drug Development and Diverse Chemical-Biology Applications

Researchers explore the potential of click chemistry for drug development and diverse chemical-biology applications. Click chemistry is a newer approach to the synthesis of drug-like molecules that can accelerate the drug discovery process by utilizing a few practical and reliable reactions. Researchers have defined the click reaction as wide in scope and easy to perform, which uses only readily available reagents and is insensitive to oxygen and water. Some of the attributes of click reactions include many of these components being derived from derived from alkenes and alkynes, along with from the cracking of petroleum and many of these reactions involve the formation of carbon-heteroatom bonds. Click chemistry-based drug discovery are mainly of three types, such as high-throughput screening, fragment-based drug discovery, and dynamic template-assisted strategies in fragment-based drug discovery.